CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis

• Published in: Tumor biology 2013-04, Vol.34 (2), p.1215-1224
• Main Authors: Jiang, Ou, Zhou, Rongxing, Wu, Daoquan, Liu, Yu, Wu, Wenjian, Cheng, Nansheng
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Colorectal cancer; Colorectal Neoplasms - etiology; Cytochrome P-450 CYP2E1 - genetics; Genes; Genetic Predisposition to Disease; Humans; Polymorphism; Polymorphism, Genetic - genetics; Research Article; Review Literature as Topic; Risk Factors; Systematic review
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-013-0664-8

Studies investigating the associations between Cytochrome P4502E1 ( CYP2E1 ) polymorphisms and colorectal cancer (CRC) risk report conflicting results. We conducted a meta-analysis to assess the association between CYP2E1 gene Rsa I/Pst I, Dral T/A and 96-bp insertion polymorphisms and CRC susceptibility. Two investigators independently searched the Medline, Embase, CNKI, Wanfang, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP2E1 polymorphisms and CRC were calculated in a fixed-effect model (the Mantel–Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Ultimately, 12, 5, and 4 studies were found to be eligible for meta-analyses of Rsa I/Pst I, Dral T/A, and 96-bp insertion polymorphisms, respectively. Our analysis suggested that the variant genotype of Rsa I/Pst I were associated with a significantly increased CRC risk (c2/c2 vs. c1/c1, OR = 1.36, 95 % CI = 1.04–1.77; recessive model, OR = 1.35, 95 % CI = 1.04–1.75). Moreover, similar results were observed between CYP2E1 96-bp insertion polymorphism and CRC risk (dominant model, OR = 1.25, 95 % CI = 1.07–1.45), while no association was observed between CYP2E1 Dral T/A polymorphism and CRC susceptibility in any genetic model. No publication bias was found in the present study. This meta-analysis shows that CYP2E1 Rsa I/Pst I and 96-bp insertion polymorphisms may be associated with CRC risk. The CYP2E1 Dral T/A polymorphism was not detected to be related to the risk for CRC.