Single HCC in Cirrhotic Patients: Liver Resection or Liver Transplantation? Long-term Outcome According to an Intention-to-treat Basis

ABSTRACT Background Compensated cirrhotic patients with single hepatocellular carcinoma (HCC) ≤5 cm may benefit from both liver resection (LR) and liver transplantation (LT); however, the better 10-year actuarial survival of the two treatments remains unclear. We aimed to assess the long-term outcom...

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Bibliographic Details
Published in:Annals of surgical oncology 2013-04, Vol.20 (4), p.1194-1202
Main Authors: Sapisochin, Gonzalo, Castells, Lluis, Dopazo, Cristina, Bilbao, Itxarone, Minguez, Beatriz, Lázaro, Jose Luis, Allende, Helena, Balsells, Joaquin, Caralt, Mireia, Charco, Ramón
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - therapy
Female
Follow-Up Studies
Hepatectomy - mortality
Hepatobiliary Tumors
Humans
Intention
Liver Cirrhosis - complications
Liver Cirrhosis - mortality
Liver Cirrhosis - therapy
Liver Neoplasms - etiology
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Liver Transplantation - mortality
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Oncology
Postoperative Complications
Prognosis
Prospective Studies
Retrospective Studies
Surgery
Surgical Oncology
Survival Rate
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Summary:ABSTRACT Background Compensated cirrhotic patients with single hepatocellular carcinoma (HCC) ≤5 cm may benefit from both liver resection (LR) and liver transplantation (LT); however, the better 10-year actuarial survival of the two treatments remains unclear. We aimed to assess the long-term outcome of cirrhotic patients with single HCC ≤5 cm treated either with LR or LT on an intention-to-treat basis. Methods A total of 217 cirrhotic patients with single HCC ≤5 cm were evaluated at our department: 95 were treated with LR (LR group), and 122 were included on the waiting list for LT (LT group). Patients in the LR group were divided into very early HCC (tumor size ≤2 cm) and early HCC (tumor size >2 cm). Median follow-up was 5.3 (range 0.1–18) years. Results Tumor recurrence was 72 % in the LR group versus 16 % in the LT group ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-012-2655-1