How winner cells cause the demise of loser cells: cell competition causes apoptosis of suboptimal cells: their dregs are removed by hemocytes, thus preserving tissue homeostasis

Recent results show that, during the process known as cell competition, winner cells identify and kill viable cells from a growing population without requiring engulfment. The engulfment machinery is mainly required in circulating macrophages (hemocytes) after the discrimination between winners and...

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Bibliographic Details
Published in:BioEssays 2013-04, Vol.35 (4), p.348-353
Main Authors: Lolo, Fidel-Nicolás, Casas Tintó, Sergio, Moreno, Eduardo
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Cell Communication
Cell Proliferation
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Hemocytes - physiology
Homeostasis
Humans
Macrophages - physiology
Mice
Signal Transduction
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Summary:Recent results show that, during the process known as cell competition, winner cells identify and kill viable cells from a growing population without requiring engulfment. The engulfment machinery is mainly required in circulating macrophages (hemocytes) after the discrimination between winners and losers is completed and the losers have been killed and extruded from the epithelium. Those new results leave us with the question as to which molecules allow winner cells to recognize and impose cell death on the loser cells during cell competition.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.201200156