Diagnostic performance of regional DTI-derived tensor metrics in glioblastoma multiforme: simultaneous evaluation of p, q, L, Cl, Cp, Cs, RA, RD, AD, mean diffusivity and fractional anisotropy

Objectives Almost a dozen diffusion tensor-imaging (DTI) variables have been used to evaluate brain tumours with scarce information about their diagnostic ability. We aimed to perform a comprehensive evaluation of tensor metrics reported in the last decade. Methods Retrospective case control study p...

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Bibliographic Details
Published in:European radiology 2013-04, Vol.23 (4), p.1112-1121
Main Authors: Cortez-Conradis, David, Favila, Rafael, Isaac-Olive, Keila, Martinez-Lopez, Manuel, Rios, Camilo, Roldan-Valadez, Ernesto
Format: Article
Language:English
Subjects:
Adult
Aged
Algorithms
Anisotropy
Biomarkers
Brain cancer
Brain Neoplasms - pathology
Diagnostic Radiology
Diffusion Tensor Imaging - methods
Edema
Eigenvalues
Female
Glioblastoma - pathology
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neuro
Neuroradiology
Radiology
Reproducibility of Results
Sensitivity and Specificity
Tumors
Ultrasound
Young Adult
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Summary:Objectives Almost a dozen diffusion tensor-imaging (DTI) variables have been used to evaluate brain tumours with scarce information about their diagnostic ability. We aimed to perform a comprehensive evaluation of tensor metrics reported in the last decade. Methods Retrospective case control study performed in 14 patients with glioblastoma multiforme (GBM) and 28 controls. Conventional brain MR sequences and image postprocessing of DTI allowed the calculation of: MD, FA, p, q, L, Cl, Cp, Cs, RA, RD and AD, classified into five regions: normal appearance white matter (NAWM), immediate and distant oedema, enhancing rim and cystic cavity. ANOVA and AUROC analyses were performed. Results ANOVA depicted a significant difference among all metrics ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-012-2688-7