Alterations in Adipokines in Feline Hepatic Lipidosis

• Published in: Journal of veterinary internal medicine 2013-03, Vol.27 (2), p.242-249
• Main Authors: Mazaki-Tovi, M., Abood, S.K., Segev, G., Schenck, P.A.
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectin - blood; Alanine Transaminase - blood; Alkaline Phosphatase - blood; Animals; Body fat; Cat Diseases - blood; Cat Diseases - diagnostic imaging; Cat Diseases - enzymology; Cats; Female; Insulin; Insulin resistance; Leptin; Leptin - blood; Lipidoses - blood; Lipidoses - diagnostic imaging; Lipidoses - enzymology; Lipidoses - veterinary; Lipids; Liver Diseases - blood; Liver Diseases - diagnostic imaging; Liver Diseases - enzymology; Liver Diseases - veterinary; Male; Obesity; Statistics, Nonparametric; Triglyceride; Ultrasonography
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.12055

Background Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid‐lowering and insulin‐sensitizing effects. Hypothesis Serum concentrations of adiponectin and leptin are altered in feline HL. Animals Client‐owned cats: 55 healthy and 45 with liver disease. Methods Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined. Results Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 μg/mL), HL and concurrent disease (4.4 μg/mL), or other liver disease (6.1 μg/mL), as compared with healthy cats (1.5 μg/mL; P