Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats

It is suggested that iron may play a role in the pathogenesis of diabetes. Iron is not only chaperoned through its essential functional pathways, but it also causes damage to biological systems by catalyzing the production of reactive oxygen species. So, the parenchymal tissues of several organs are...

Full description

Saved in:
Bibliographic Details
Published in:Journal of trace elements in medicine and biology 2013-04, Vol.27 (2), p.143-147
Main Authors: Saravanan, Ganapathy, Ponmurugan, Ponnusamy, Begum, Mustapha Shabana
Format: Article
Language:English
Subjects:
Aminolevulinic Acid - metabolism
Aminolevulinic acid dehydratase
Animals
Blood Glucose - metabolism
Cysteine - analogs & derivatives
Cysteine - pharmacology
Diabetes
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - metabolism
Ferritins - metabolism
Heme oxygenase
Heme Oxygenase (Decyclizing) - metabolism
Insulin - blood
Iron - metabolism
Kidney - drug effects
Kidney - metabolism
Liver - drug effects
Liver - metabolism
Male
Rats
Rats, Wistar
S-allylcysteine
Sulfur - metabolism
Transferrin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is suggested that iron may play a role in the pathogenesis of diabetes. Iron is not only chaperoned through its essential functional pathways, but it also causes damage to biological systems by catalyzing the production of reactive oxygen species. So, the parenchymal tissues of several organs are subject to cell injury and functional insufficiency due to excess deposition of iron. The present study investigated the effects of S-allylcysteine (SAC), a sulphur containing amino acid derived from garlic on the changes in iron metabolism induced by oxidative stress in tissues, as well as on serum biochemical parameters of streptozotocin (STZ)-induced diabetic rats. SAC was administered orally for 45days to control and experimental diabetic rats. The effects of SAC on glucose, insulin, serum iron, ferritin, transferrin, serum bilirubin, heart heme oxygenase activity (HO) and δ-aminolevulinicacid dehydratase activity (δ-ALA-D) in liver and kidneys were studied. The levels of glucose, iron, ferritin, bilirubin and HO in liver were increased significantly (p
ISSN:0946-672X
1878-3252
DOI:10.1016/j.jtemb.2012.07.009