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Age-related changes in gonadal and serotonergic axes of broiler breeder roosters
Fertility of domestic roosters decreases at ∼50 wk of age. In a previous study on aging white leghorn roosters, low fertility was accompanied by low levels of both hypothalamic vasoactive intestinal peptide (VIP) and pituitary prolactin (PRL) mRNA expression; however, their role in aging broiler bre...
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| Published in: | Domestic animal endocrinology 2013-04, Vol.44 (3), p.145-150 |
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| container_title | Domestic animal endocrinology |
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| creator | Avital-Cohen, N. Heiblum, R. Argov-Argaman, N. Rosenstrauch, A. Chaiseha, Y. Mobarkey, N. Rozenboim, I. |
| description | Fertility of domestic roosters decreases at ∼50 wk of age. In a previous study on aging white leghorn roosters, low fertility was accompanied by low levels of both hypothalamic vasoactive intestinal peptide (VIP) and pituitary prolactin (PRL) mRNA expression; however, their role in aging broiler breeder rooster reproduction is still unclear. In this study we compared reproductive activities of young (35-wk-old) and aging (73-wk-old) broiler breeder roosters. Weekly semen volume; concentration and ejaculation grade; and concentrations of plasma testosterone, estradiol, and PRL were examined. Every other week, 10 roosters from each group were euthanized, their testes weighed, and hypothalamus and pituitary removed to determine mRNA expression of hypothalamic GnRH-I, pituitary FSH, pituitary LH, hypothalamic VIP, and pituitary PRL. Aging roosters had significantly lower testis weight and semen volume, sperm concentration, ejaculation grade and plasma testosterone and low hypothalamic GnRH-I, pituitary FSH, and pituitary LH mRNA expression than young roosters (P ≤ 0.05). Aging roosters had higher concentrations of plasma estradiol and PRL and higher hypothalamic VIP and pituitary PRL mRNA expression than young roosters (P ≤ 0.05). We suggest that PRL, which is known to inhibit the gonadal axis, and its releasing factor, VIP, play an important role in the reproductive failure associated with age in broiler breeder roosters. |
| doi_str_mv | 10.1016/j.domaniend.2013.01.002 |
| format | article |
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In a previous study on aging white leghorn roosters, low fertility was accompanied by low levels of both hypothalamic vasoactive intestinal peptide (VIP) and pituitary prolactin (PRL) mRNA expression; however, their role in aging broiler breeder rooster reproduction is still unclear. In this study we compared reproductive activities of young (35-wk-old) and aging (73-wk-old) broiler breeder roosters. Weekly semen volume; concentration and ejaculation grade; and concentrations of plasma testosterone, estradiol, and PRL were examined. Every other week, 10 roosters from each group were euthanized, their testes weighed, and hypothalamus and pituitary removed to determine mRNA expression of hypothalamic GnRH-I, pituitary FSH, pituitary LH, hypothalamic VIP, and pituitary PRL. Aging roosters had significantly lower testis weight and semen volume, sperm concentration, ejaculation grade and plasma testosterone and low hypothalamic GnRH-I, pituitary FSH, and pituitary LH mRNA expression than young roosters (P ≤ 0.05). Aging roosters had higher concentrations of plasma estradiol and PRL and higher hypothalamic VIP and pituitary PRL mRNA expression than young roosters (P ≤ 0.05). We suggest that PRL, which is known to inhibit the gonadal axis, and its releasing factor, VIP, play an important role in the reproductive failure associated with age in broiler breeder roosters.</description><identifier>ISSN: 0739-7240</identifier><identifier>EISSN: 1879-0054</identifier><identifier>DOI: 10.1016/j.domaniend.2013.01.002</identifier><identifier>PMID: 23411011</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Age Factors ; Aging ; Animals ; broiler breeders ; Chickens - blood ; Chickens - physiology ; ejaculation ; estradiol ; Estradiol - blood ; Follicle Stimulating Hormone - biosynthesis ; Follicle Stimulating Hormone - genetics ; follicle-stimulating hormone ; gene expression ; Gonadotropin-Releasing Hormone - biosynthesis ; Gonadotropin-Releasing Hormone - blood ; Gonadotropin-Releasing Hormone - genetics ; hypothalamus ; Hypothalamus - metabolism ; Hypothalamus - physiology ; luteinizing hormone ; Luteinizing Hormone - biosynthesis ; Luteinizing Hormone - blood ; Luteinizing Hormone - genetics ; Male ; messenger RNA ; Pituitary Gland - metabolism ; Pituitary Gland - physiology ; Prolactin ; Prolactin - blood ; Real-Time Polymerase Chain Reaction - veterinary ; Reproduction ; Reproduction - physiology ; Reverse Transcriptase Polymerase Chain Reaction - veterinary ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; roosters ; semen ; Semen - physiology ; Semen quality ; Serotonergic Neurons - physiology ; sperm concentration ; testes ; Testis - anatomy & histology ; Testis - physiology ; testosterone ; Testosterone - blood ; Vasoactive intestinal peptide ; Vasoactive Intestinal Peptide - biosynthesis ; Vasoactive Intestinal Peptide - blood ; Vasoactive Intestinal Peptide - genetics ; White Leghorn</subject><ispartof>Domestic animal endocrinology, 2013-04, Vol.44 (3), p.145-150</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-bda1e505d3719c32c2fffe10d5fa511f38cbe8a88006bdc2437be43894466a8e3</citedby><cites>FETCH-LOGICAL-c395t-bda1e505d3719c32c2fffe10d5fa511f38cbe8a88006bdc2437be43894466a8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23411011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avital-Cohen, N.</creatorcontrib><creatorcontrib>Heiblum, R.</creatorcontrib><creatorcontrib>Argov-Argaman, N.</creatorcontrib><creatorcontrib>Rosenstrauch, A.</creatorcontrib><creatorcontrib>Chaiseha, Y.</creatorcontrib><creatorcontrib>Mobarkey, N.</creatorcontrib><creatorcontrib>Rozenboim, I.</creatorcontrib><title>Age-related changes in gonadal and serotonergic axes of broiler breeder roosters</title><title>Domestic animal endocrinology</title><addtitle>Domest Anim Endocrinol</addtitle><description>Fertility of domestic roosters decreases at ∼50 wk of age. In a previous study on aging white leghorn roosters, low fertility was accompanied by low levels of both hypothalamic vasoactive intestinal peptide (VIP) and pituitary prolactin (PRL) mRNA expression; however, their role in aging broiler breeder rooster reproduction is still unclear. In this study we compared reproductive activities of young (35-wk-old) and aging (73-wk-old) broiler breeder roosters. Weekly semen volume; concentration and ejaculation grade; and concentrations of plasma testosterone, estradiol, and PRL were examined. Every other week, 10 roosters from each group were euthanized, their testes weighed, and hypothalamus and pituitary removed to determine mRNA expression of hypothalamic GnRH-I, pituitary FSH, pituitary LH, hypothalamic VIP, and pituitary PRL. Aging roosters had significantly lower testis weight and semen volume, sperm concentration, ejaculation grade and plasma testosterone and low hypothalamic GnRH-I, pituitary FSH, and pituitary LH mRNA expression than young roosters (P ≤ 0.05). Aging roosters had higher concentrations of plasma estradiol and PRL and higher hypothalamic VIP and pituitary PRL mRNA expression than young roosters (P ≤ 0.05). We suggest that PRL, which is known to inhibit the gonadal axis, and its releasing factor, VIP, play an important role in the reproductive failure associated with age in broiler breeder roosters.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>broiler breeders</subject><subject>Chickens - blood</subject><subject>Chickens - physiology</subject><subject>ejaculation</subject><subject>estradiol</subject><subject>Estradiol - blood</subject><subject>Follicle Stimulating Hormone - biosynthesis</subject><subject>Follicle Stimulating Hormone - genetics</subject><subject>follicle-stimulating hormone</subject><subject>gene expression</subject><subject>Gonadotropin-Releasing Hormone - biosynthesis</subject><subject>Gonadotropin-Releasing Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - genetics</subject><subject>hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus - physiology</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - biosynthesis</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - genetics</subject><subject>Male</subject><subject>messenger RNA</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary Gland - physiology</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Real-Time Polymerase Chain Reaction - veterinary</subject><subject>Reproduction</subject><subject>Reproduction - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - veterinary</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>roosters</subject><subject>semen</subject><subject>Semen - physiology</subject><subject>Semen quality</subject><subject>Serotonergic Neurons - physiology</subject><subject>sperm concentration</subject><subject>testes</subject><subject>Testis - anatomy & histology</subject><subject>Testis - physiology</subject><subject>testosterone</subject><subject>Testosterone - blood</subject><subject>Vasoactive intestinal peptide</subject><subject>Vasoactive Intestinal Peptide - biosynthesis</subject><subject>Vasoactive Intestinal Peptide - blood</subject><subject>Vasoactive Intestinal Peptide - genetics</subject><subject>White Leghorn</subject><issn>0739-7240</issn><issn>1879-0054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkE1P3DAQhq2KCrbAXyg5ckk6Eztr57hCfFRCaqXC2XLscepVNqZ2FrX_HqMFrj1Yrw_POzN6GLtAaBBw_W3buLgzc6DZNS0gbwAbgPYTW6GSfQ3QiSO2Asn7WrYCTtiXnLcAIEv7mJ20XGD54Yr93IxUJ5rMQq6yv808Uq7CXI1xNs5MlZldlSnFJc6UxmAr87cA0VdDimGiVJLIlUwx5oVSPmOfvZkynb_lKXu8uX64uqvvf9x-v9rc15b33VIPziB10Dkusbe8ta33nhBc502H6LmyAymjFMB6cLYVXA4kuOqFWK-NIn7KLg9zn1L8s6e86F3IlqbJzBT3WSNHqTqJ2BZUHlCbYs6JvH5KYWfSP42gX3Xqrf7QqV91akBddJbm17cl-2FH7qP37q8AFwfAm6jNmELWj7_KBAHldShUITYHgoqM50BJZ1v2WHIhkV3K4vDfM14APp-T1Q</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Avital-Cohen, N.</creator><creator>Heiblum, R.</creator><creator>Argov-Argaman, N.</creator><creator>Rosenstrauch, A.</creator><creator>Chaiseha, Y.</creator><creator>Mobarkey, N.</creator><creator>Rozenboim, I.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Age-related changes in gonadal and serotonergic axes of broiler breeder roosters</title><author>Avital-Cohen, N. ; Heiblum, R. ; Argov-Argaman, N. ; Rosenstrauch, A. ; Chaiseha, Y. ; Mobarkey, N. ; Rozenboim, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-bda1e505d3719c32c2fffe10d5fa511f38cbe8a88006bdc2437be43894466a8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>broiler breeders</topic><topic>Chickens - blood</topic><topic>Chickens - physiology</topic><topic>ejaculation</topic><topic>estradiol</topic><topic>Estradiol - blood</topic><topic>Follicle Stimulating Hormone - biosynthesis</topic><topic>Follicle Stimulating Hormone - genetics</topic><topic>follicle-stimulating hormone</topic><topic>gene expression</topic><topic>Gonadotropin-Releasing Hormone - biosynthesis</topic><topic>Gonadotropin-Releasing Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - genetics</topic><topic>hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - biosynthesis</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - genetics</topic><topic>Male</topic><topic>messenger RNA</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary Gland - physiology</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Real-Time Polymerase Chain Reaction - veterinary</topic><topic>Reproduction</topic><topic>Reproduction - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - veterinary</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>roosters</topic><topic>semen</topic><topic>Semen - physiology</topic><topic>Semen quality</topic><topic>Serotonergic Neurons - physiology</topic><topic>sperm concentration</topic><topic>testes</topic><topic>Testis - anatomy & histology</topic><topic>Testis - physiology</topic><topic>testosterone</topic><topic>Testosterone - blood</topic><topic>Vasoactive intestinal peptide</topic><topic>Vasoactive Intestinal Peptide - biosynthesis</topic><topic>Vasoactive Intestinal Peptide - blood</topic><topic>Vasoactive Intestinal Peptide - genetics</topic><topic>White Leghorn</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avital-Cohen, N.</creatorcontrib><creatorcontrib>Heiblum, R.</creatorcontrib><creatorcontrib>Argov-Argaman, N.</creatorcontrib><creatorcontrib>Rosenstrauch, A.</creatorcontrib><creatorcontrib>Chaiseha, Y.</creatorcontrib><creatorcontrib>Mobarkey, N.</creatorcontrib><creatorcontrib>Rozenboim, I.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avital-Cohen, N.</au><au>Heiblum, R.</au><au>Argov-Argaman, N.</au><au>Rosenstrauch, A.</au><au>Chaiseha, Y.</au><au>Mobarkey, N.</au><au>Rozenboim, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related changes in gonadal and serotonergic axes of broiler breeder roosters</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>44</volume><issue>3</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0739-7240</issn><eissn>1879-0054</eissn><abstract>Fertility of domestic roosters decreases at ∼50 wk of age. In a previous study on aging white leghorn roosters, low fertility was accompanied by low levels of both hypothalamic vasoactive intestinal peptide (VIP) and pituitary prolactin (PRL) mRNA expression; however, their role in aging broiler breeder rooster reproduction is still unclear. In this study we compared reproductive activities of young (35-wk-old) and aging (73-wk-old) broiler breeder roosters. Weekly semen volume; concentration and ejaculation grade; and concentrations of plasma testosterone, estradiol, and PRL were examined. Every other week, 10 roosters from each group were euthanized, their testes weighed, and hypothalamus and pituitary removed to determine mRNA expression of hypothalamic GnRH-I, pituitary FSH, pituitary LH, hypothalamic VIP, and pituitary PRL. Aging roosters had significantly lower testis weight and semen volume, sperm concentration, ejaculation grade and plasma testosterone and low hypothalamic GnRH-I, pituitary FSH, and pituitary LH mRNA expression than young roosters (P ≤ 0.05). Aging roosters had higher concentrations of plasma estradiol and PRL and higher hypothalamic VIP and pituitary PRL mRNA expression than young roosters (P ≤ 0.05). We suggest that PRL, which is known to inhibit the gonadal axis, and its releasing factor, VIP, play an important role in the reproductive failure associated with age in broiler breeder roosters.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23411011</pmid><doi>10.1016/j.domaniend.2013.01.002</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier |
| subjects | Age Factors Aging Animals broiler breeders Chickens - blood Chickens - physiology ejaculation estradiol Estradiol - blood Follicle Stimulating Hormone - biosynthesis Follicle Stimulating Hormone - genetics follicle-stimulating hormone gene expression Gonadotropin-Releasing Hormone - biosynthesis Gonadotropin-Releasing Hormone - blood Gonadotropin-Releasing Hormone - genetics hypothalamus Hypothalamus - metabolism Hypothalamus - physiology luteinizing hormone Luteinizing Hormone - biosynthesis Luteinizing Hormone - blood Luteinizing Hormone - genetics Male messenger RNA Pituitary Gland - metabolism Pituitary Gland - physiology Prolactin Prolactin - blood Real-Time Polymerase Chain Reaction - veterinary Reproduction Reproduction - physiology Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA, Messenger - chemistry RNA, Messenger - genetics roosters semen Semen - physiology Semen quality Serotonergic Neurons - physiology sperm concentration testes Testis - anatomy & histology Testis - physiology testosterone Testosterone - blood Vasoactive intestinal peptide Vasoactive Intestinal Peptide - biosynthesis Vasoactive Intestinal Peptide - blood Vasoactive Intestinal Peptide - genetics White Leghorn |
| title | Age-related changes in gonadal and serotonergic axes of broiler breeder roosters |
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