Improvement of p-cymene antinociceptive and anti-inflammatory effects by inclusion in β-cyclodextrin

Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short half-life is a limitation for p-cymene application and several approaches have been used to improve pharmaceutical properties of monoterpenes, including the employment of drug-delivery systems. Here, we used p...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2013-03, Vol.20 (5), p.436-440
Main Authors: de Souza Siqueira Quintans, Jullyana, Menezes, Paula Passos, Santos, Márcio Roberto Viana, Bonjardim, Leonardo Rigoldi, Almeida, Jackson Roberto Guedes Silva, Gelain, Daniel Pens, Araújo, Adriano Antunes de Souza, Quintans-Júnior, Lucindo José
Format: Article
Language:English
Subjects:
Acetic Acid - adverse effects
Analgesics - chemistry
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - therapeutic use
Anti-inflammatory drugs
Behavior, Animal
beta-Cyclodextrins - administration & dosage
beta-Cyclodextrins - therapeutic use
Carrageenan - pharmacology
Cyclodextrin
Cyclodextrins
Drug Evaluation, Preclinical
Edema - drug therapy
Health aspects
Hot Temperature
Inflammation
Macromolecular Substances - chemistry
Male
Medicine, Botanic
Medicine, Herbal
Mice
Monoterpene
Monoterpenes - administration & dosage
Monoterpenes - chemistry
Monoterpenes - isolation & purification
Monoterpenes - therapeutic use
p-Cymene
Pain
Pain Measurement - methods
Phytotherapy
Time Factors
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Summary:Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short half-life is a limitation for p-cymene application and several approaches have been used to improve pharmaceutical properties of monoterpenes, including the employment of drug-delivery systems. Here, we used p-cymene/β-cyclodextrin (β-CD) complex and p-cymene (PC) isolated to evaluated whether the complex formulation is able to improve the antinociceptive activity of this monoterpene. Male mice (26–30g) were pretreated with PC/β-CD (20 or 40mg/kg, p.o.), PC (20 or 40mg/kg, p.o.) or vehicle (distilled water), 0.5h before painful tests and antinociceptive effect was evaluated at times: 0.5, 1, 2, 4, 8, and 16h after treatment. We evaluated the analgesic-like effect of PC/β-CD and PC in acetic acid-induced abdominal writhes, hot-plate, carrageenan-induced paw edema and in rota-rod apparatus. Our results demonstrated that acute treatment with complex PC/β-CD produced an antinocicepitve effect (p
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2012.12.009