Assessment of immunoglobulin G4–positive cell infiltration in myopathic heart tissue from patients with severe heart failure

Among 50 patients, the grade of inflammatory cell infiltrates was estimated as (n [%]) negative (0 [0%]), mild (29 [58%]), moderate (15 [30%]), and severe (6 [12%]) in the myocardial regions and negative (0 [0%]), mild (28 [56%]), moderate (14 [28%]), and severe (8 [16%]) in the epicardial regions (...

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Bibliographic Details
Published in:Human pathology 2013-04, Vol.44 (4), p.676-678
Main Authors: Teramoto, Kunihiro, MD, Terasaki, Fumio, MD, Isomura, Tadashi, MD, Ishizaka, Nobukazu, MD
Format: Article
Language:English
Subjects:
Cardiomyopathies - immunology
Cardiomyopathies - pathology
Cardiomyopathies - physiopathology
Cardiomyopathies - surgery
Disease
Female
Heart - physiopathology
Heart attacks
Heart failure
Heart Failure - immunology
Heart Failure - pathology
Heart Failure - physiopathology
Heart Failure - surgery
Heart Function Tests
Heart Ventricles - surgery
Humans
Immunoglobulin G - metabolism
Male
Middle Aged
Myocardium - immunology
Myocardium - pathology
Pathology
Pericardium - immunology
Pericardium - pathology
Plasma Cells - immunology
Plasma Cells - pathology
Sarcoidosis
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Summary:Among 50 patients, the grade of inflammatory cell infiltrates was estimated as (n [%]) negative (0 [0%]), mild (29 [58%]), moderate (15 [30%]), and severe (6 [12%]) in the myocardial regions and negative (0 [0%]), mild (28 [56%]), moderate (14 [28%]), and severe (8 [16%]) in the epicardial regions (Fig.); some cells of which were identified as CD45-positive lymphocytes. [...]more than 42% and 44% of moderate grade or higher inflammatory cell infiltrates were observed in the myocardial and epicardial regions, respectively; on the other hand, only mild IgG4-positive plasma cell infiltrates were observed in the epicardium in 4 patients (8%; Fig. [...]there was no evidence of intramyocardial IgG4-positive cell infiltrates in patients with severe heart failure, although they were present, albeit not frequently, in the epicardial regions.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2012.11.020