Thrombosis in vasculitis

Thrombo-embolic disease is an increasingly recognised complication of several vasculitides. A common observation is that thrombo-embolic complications coincide with periods of increased vasculitis disease activity, but the mechanism through which this happens is still unknown. Thrombo-embolic diseas...

Full description

Saved in:
Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2013-02, Vol.27 (1), p.57-67
Main Author: Gaffo, Angelo L., MD MsPH
Format: Article
Language:English
Subjects:
ANCA vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications
Behçet's disease
Cardiovascular Diseases - etiology
Humans
Rheumatology
Risk Factors
Thrombo-embolic disease
Thrombosis
Vasculitis
Vasculitis - complications
Vasculitis - physiopathology
Venous Thromboembolism - etiology
Venous Thromboembolism - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thrombo-embolic disease is an increasingly recognised complication of several vasculitides. A common observation is that thrombo-embolic complications coincide with periods of increased vasculitis disease activity, but the mechanism through which this happens is still unknown. Thrombo-embolic disease has been recognised for decades as a significant contributor to the morbidity and mortality of Behçet's disease, and the role of anticoagulation in its management is being minimised in favour of immunosuppression, although evidence from randomised controlled trials is lacking. Ancillary data from a randomised clinical trial and retrospective observational studies have confirmed an association between venous thrombo-embolic disease and vasculitides associated with anti-neutrophil cytoplasmic antibodies (ANCAs). An increased cardiovascular risk is now also recognised for vasculitides associated with ANCAs. Thrombosis plays a prominent role in the pathogenesis of thromboangiitis obliterans (Buerger's disease). The association of thrombosis with other vasculitides such as giant-cell arteritis and levamisole-induced vasculopathy is under investigation.
ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2012.12.005