The SLC12 family of electroneutral cation-coupled chloride cotransporters

The SLC12 family encodes electroneutral cation-coupled chloride cotransporters that are critical for several physiological processes including cell volume regulation, modulation of intraneuronal chloride concentration, transepithelial ion movement, and blood pressure regulation. Members of this fami...

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Bibliographic Details
Published in:Molecular aspects of medicine 2013-04, Vol.34 (2-3), p.288-298
Main Authors: Arroyo, Juan Pablo, Kahle, Kristopher T., Gamba, Gerardo
Format: Article
Language:English
Subjects:
Blood Pressure - genetics
Blood Pressure - physiology
Diuretics
Diuretics - pharmacology
Epilepsy
Humans
Hypertension
K Cl- Cotransporters
Models, Biological
Models, Molecular
Multigene Family - genetics
Psoriasis
SLC12
Sodium-Potassium-Chloride Symporters - genetics
Sodium-Potassium-Chloride Symporters - metabolism
Sodium-Potassium-Chloride Symporters - physiology
Symporters - genetics
Symporters - metabolism
Symporters - physiology
WNK
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Summary:The SLC12 family encodes electroneutral cation-coupled chloride cotransporters that are critical for several physiological processes including cell volume regulation, modulation of intraneuronal chloride concentration, transepithelial ion movement, and blood pressure regulation. Members of this family are the targets of the most commonly used diuretic drugs, have been shown to be the causative genes for inherited disease such as Gitelman, Bartter and Andermann syndromes, and potentially play a role in polygenic complex diseases like arterial hypertension, epilepsy, osteoporosis, and cancer.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2012.05.002