Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52

Riboflavin, a water-soluble vitamin also known as vitamin B2, is essential for normal cellular functions. Riboflavin transporters play important roles in its homeostasis. Recently, three novel riboflavin transporters were identified, and designated as RFT1, RFT2 and RFT3. Because the RFTs did not sh...

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Bibliographic Details
Published in:Molecular aspects of medicine 2013-04, Vol.34 (2-3), p.693-701
Main Authors: Yonezawa, Atsushi, Inui, Ken-ichi
Format: Article
Language:English
Subjects:
Absorption
Brown-Vialetto-Van Laere (BVVL) syndrome
Bulbar Palsy, Progressive - genetics
Bulbar Palsy, Progressive - metabolism
Cloning, Molecular
Hearing Loss, Sensorineural - genetics
Hearing Loss, Sensorineural - metabolism
Humans
Membrane Transport Proteins - genetics
Membrane Transport Proteins - metabolism
Membrane Transport Proteins - physiology
Models, Molecular
Molecular Structure
Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics
Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism
Multiple acyl-CoA dehydrogenase deficiency (MADD)
Phenotype
Phylogeny
Polymorphism, Genetic
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
Receptors, G-Protein-Coupled - physiology
RFT
RFVT
Riboflavin
Riboflavin - metabolism
SLC52
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Summary:Riboflavin, a water-soluble vitamin also known as vitamin B2, is essential for normal cellular functions. Riboflavin transporters play important roles in its homeostasis. Recently, three novel riboflavin transporters were identified, and designated as RFT1, RFT2 and RFT3. Because the RFTs did not show similarity to other SLC transporters, and RFT1 and RFT3 are similar in sequence and function, they were assigned into a new SLC family, SLC52. Subsequently, RFT1/GPR172B, RFT3/GPR172A and RFT2/C20orf54 were renamed as RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3, respectively. In this review, we summarize recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2012.07.014