Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma

Radiation-induced sarcomas represent a rare delayed-late secondary complication of radiation therapy. Radiation-associated sarcomas are associated with a worse overall prognosis compared to sporadic sarcomas irrespective of histological type. Herein we report a case of a 65-year old man who underwen...

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Bibliographic Details
Published in:Journal of neuro-oncology 2013-03, Vol.112 (1), p.115-118
Main Authors: Mazbani, Edmond, Jones, Robin L., Fink, James, Chamberlain, Marc C.
Format: Article
Language:English
Subjects:
Aged
Astrocytoma
Brain tumors
Case reports
Clinical Study
Glioma
Glioma - diagnostic imaging
Humans
Male
Medicine
Medicine & Public Health
Metastases
Neoplasms, Radiation-Induced - diagnostic imaging
Neoplasms, Radiation-Induced - etiology
Neurology
Oncology
Positron-Emission Tomography
Prognosis
Radiation
Radiotherapy - adverse effects
Rhabdomyosarcoma
Rhabdomyosarcoma - diagnostic imaging
Rhabdomyosarcoma - etiology
Sarcoma
Spinal cord
Spinal Cord Neoplasms - diagnostic imaging
Spine (lumbar)
Surgery
Thorax
Tomography, X-Ray Computed
Tumors
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Summary:Radiation-induced sarcomas represent a rare delayed-late secondary complication of radiation therapy. Radiation-associated sarcomas are associated with a worse overall prognosis compared to sporadic sarcomas irrespective of histological type. Herein we report a case of a 65-year old man who underwent surgery and radiation therapy for a T4 spinal cord low-grade two astrocytoma in 1965 and presented over 40 years later with spinal cord complex intramedullary tumor involving the thoracic cord with drop metastases in the lumbar spine. Histology from a partial resection of the thoracic spinal tumor revealed a high-grade rhabdomyosarcoma. In addition to the rarity of radiation-induced sarcoma arising following the treatment of a spinal cord glioma, this case study represents one of the first reports of a spinal cord rhabdomyosarcoma arising in this setting.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-012-1042-x