Pluripotent Stem Cell―Derived Hepatocytes: Potential and Challenges in Pharmacology

The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many source...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2013-01, Vol.53 (1), p.147-159
Main Authors: SZKOLNICKA, Dagmara, WENLI ZHOU, LUCENDO-VILLARIN, Balta, HAY, David C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Digestive system
Hepatocytes - cytology
Humans
Liver - cytology
Medical sciences
Pharmacology. Drug treatments
Pluripotent Stem Cells - cytology
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Summary:The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many sources, including human stem cell populations. These models offer new opportunities to further our understanding of human liver biology from diverse genotypes and, in the future, to facilitate the development of novel medicines or cell-based therapies. This review discusses limitations in current cell-based models and the advantages offered by pluripotent stem cell-derived hepatocytes.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev-pharmtox-011112-140306