Hemangioblastoma of the Gastrointestinal Tract: A First Case

We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed a...

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Bibliographic Details
Published in:International journal of surgical pathology 2013-04, Vol.21 (2), p.192-196
Main Authors: Casadei Gardini, Andrea, Pieri, Federica, Fusaroli, Pietro, Oboldi, Devil, Passardi, Alessandro, Monti, Manlio, Rosetti, Paola, Calpona, Sebastiano, Valgiusti, Martina, Ragazzini, Angela, Amadori, Dino, Frassineti, Giovanni Luca
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - analysis
Breast Neoplasms - pathology
Female
Gastrointestinal Neoplasms - metabolism
Gastrointestinal Neoplasms - pathology
Hemangioblastoma - metabolism
Hemangioblastoma - pathology
Humans
Immunohistochemistry
Neoplasms, Second Primary - pathology
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Summary:We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion originating from the third layer of the intestinal wall; underlying layers were normal. Endoscopic ultrasound features were not suggestive of either cancer or malignant stromal tumor. Left hemicolectomy was subsequently performed due to repeated episodes of lower gastrointestinal bleeding. Grossly, a circumscribed submucosal yellowish nodule (13 mm) was observed, which was not attached to any peripheral nerve. Histologically, the lesion was composed of large, atypical cells traversed by a network of blood vessels. Immunohistochemically, the cells showed positivity for inhibin and NSE and weak positivity for S-100. A diagnosis of hemangioblastoma was made. This case highlights that hemangioblastoma of the gastrointestinal tract can also occur.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896912475082