Podoplanin and E-cadherin Expression in Preoperative Incisional Biopsies of Oral Squamous Cell Carcinoma Is Related to Lymph Node Metastases

Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early...

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Bibliographic Details
Published in:International journal of surgical pathology 2013-04, Vol.21 (2), p.133-141
Main Authors: Foschini, Maria P., Leonardi, Elisa, Eusebi, Leonardo Henry, Farnedi, Anna, Poli, Tito, Tarsitano, Achille, Cocchi, Roberto, Marchetti, Claudio, Gentile, Luciano, Sesenna, Enrico, Marucci, Gianluca, Montebugnoli, Lucio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Biopsy
Cadherins - analysis
Cadherins - biosynthesis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis - pathology
Male
Membrane Glycoproteins - analysis
Membrane Glycoproteins - biosynthesis
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
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Summary:Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896912471851