Microbial Transformation of Curcumol by Aspergillus niger

Curcumol is a representative index component for the quality control of the essential oil of Curcuma wenyujin Y.H. Chen et C. Ling, an antivirus and anticancer drug in China. Microbial transformation of curcumol (1) by Aspergillus niger AS 3.739 yielded two products. Their structures were elucidated...

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Bibliographic Details
Published in:Natural product communications 2013-02, Vol.8 (2), p.149-152
Main Authors: Li-Xia, Chen, Hui, Zhang, Qian, Zhao, Shi-Yu, Yin, Zhong, Zhang, Tian-Xian, Li, Feng, Qiu
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Aspergillus niger - metabolism
Biotransformation
Sesquiterpenes - metabolism
Sesquiterpenes - pharmacology
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Summary:Curcumol is a representative index component for the quality control of the essential oil of Curcuma wenyujin Y.H. Chen et C. Ling, an antivirus and anticancer drug in China. Microbial transformation of curcumol (1) by Aspergillus niger AS 3.739 yielded two products. Their structures were elucidated as 3α-hydroxycurcumol (2) and 3α-(4′-methoxy-succinyloxy)-curcumol (3) by extensive spectroscopic methods including 2D-NMR and HRESI-MS. Among them, 3 is a new compound. Esterification of the substrate with succinic acid is a novel reaction in the field of microbial transformation of natural products. Compound 2, the major transformation product of 1, was a high regio- and stereo-specific hydroxylation product and showed significant antiviral effects.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1300800202