Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N‐fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron‐withdrawing, an electron‐donating, and a steric...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2013-04, Vol.8 (4), p.705-708
Main Authors: Nagaki, Aiichiro, Uesugi, Yuki, Kim, Heejin, Yoshida, Jun-ichi
Format: Article
Language:English
Subjects:
Chemistry
Fluorides
Fluorides - chemistry
fluorination
lithiation
Lithium - chemistry
microreactors
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Solvents - chemistry
synthetic methods
Temperature
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Summary:Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N‐fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron‐withdrawing, an electron‐donating, and a sterically hindered functional group in good yields.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201201191