Resveratrol improves sperm motility, prevents lipid peroxidation and enhances antioxidant defences in the testes of hyperthyroid rats

• Published in: Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2013-06, Vol.37, p.31-39
• Main Authors: Ourique, Giovana M., Finamor, Isabela A., Saccol, Etiane M.H., Riffel, Ana P.K., Pês, Tanise S., Gutierrez, Karina, Gonçalves, Paulo B.D., Baldisserotto, Bernardo, Pavanato, Maria A., Barreto, Kátia P.
• Format: Article
• Language: English
• Subjects: Animals; Antioxidant enzymes; Antioxidants - pharmacology; Antioxidants - therapeutic use; Catalase - metabolism; Epididymis - drug effects; Epididymis - pathology; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; Hyperthyroidism; Hyperthyroidism - drug therapy; Hyperthyroidism - metabolism; Hyperthyroidism - pathology; Lipid Peroxidation - drug effects; Male; Organ Size - drug effects; Oxidative stress; Oxidative Stress - drug effects; Polyphenol; Prostate - drug effects; Prostate - pathology; Rats; Rats, Wistar; Sperm Motility - drug effects; Sperm quality; Stilbenes - pharmacology; Stilbenes - therapeutic use; Testicular dysfunction; Testis - drug effects; Testis - metabolism; Testis - pathology; Thiobarbituric Acid Reactive Substances - metabolism
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/j.reprotox.2013.01.006

► Resveratrol prevents the loss of sperm motility during hyperthyroidism. ► Resveratrol prevents lipid peroxidation in the testes of hyperthyroid rats. ► Resveratrol enhances antioxidant defences in the testes of hyperthyroid rats. Hyperthyroidism may lead to a loss of sperm motility and an increase in oxidative stress (OS) in testes and may cause male reproductive disorders. Thus, the use of compounds with antioxidant properties may be a strategy for preventing these disorders. The effect of resveratrol (RSV) on sperm motility and on variables of the antioxidant status in the testes of rats with triiodothyronine-induced hyperthyroidism (100μg/kg) was investigated. Hyperthyroid rats presented lower sperm motility, higher levels of lipid hydroperoxides and thiobarbituric reactive substances, lower catalase and glutathione peroxidase activities and higher glutathione-S-transferase activity in their testes than control animals. RSV treatment (1mg/kg and 10mg/kg) was able to prevent these effects in the hyperthyroid rats and had no effect in the control animals. In conclusion, RSV might be a strategy for therapeutic intervention to preserve sperm motility and to prevent OS in testes, preserving testicular function in those with hyperthyroidism.