Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats

Introduction and hypothesis Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), wh...

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Bibliographic Details
Published in:International Urogynecology Journal 2013-04, Vol.24 (4), p.683-688
Main Authors: Kitta, Takeya, Tyagi, Vikas, Nanri, Masato, Kiniwa, Mamoru, Nonomura, Katsuya, Yoshimura, Naoki
Format: Article
Language:English
Subjects:
Administration, Intravenous
Animals
Benzilates - pharmacology
Benzilates - therapeutic use
Body Weight - drug effects
Catecholamines - blood
Drug Evaluation, Preclinical
Female
Gynecology
Medicine
Medicine & Public Health
Muscarinic Antagonists - pharmacology
Muscarinic Antagonists - therapeutic use
Original Article
Rats
Rats, Sprague-Dawley
Sneezing
Urinary Incontinence - drug therapy
Urology
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Summary:Introduction and hypothesis Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats. Methods Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested. Results Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased. Conclusions Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance.
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-012-1924-7