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Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats
Introduction and hypothesis Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), wh...
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| Published in: | International Urogynecology Journal 2013-04, Vol.24 (4), p.683-688 |
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| cites | cdi_FETCH-LOGICAL-c372t-80f0267700d8a248c7c32b2dc8dc400914041e3fbbcb02154544efb667c0924f3 |
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| container_issue | 4 |
| container_start_page | 683 |
| container_title | International Urogynecology Journal |
| container_volume | 24 |
| creator | Kitta, Takeya Tyagi, Vikas Nanri, Masato Kiniwa, Mamoru Nonomura, Katsuya Yoshimura, Naoki |
| description | Introduction and hypothesis
Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats.
Methods
Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested.
Results
Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased.
Conclusions
Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance. |
| doi_str_mv | 10.1007/s00192-012-1924-7 |
| format | article |
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Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats.
Methods
Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested.
Results
Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased.
Conclusions
Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance.</description><identifier>ISSN: 0937-3462</identifier><identifier>EISSN: 1433-3023</identifier><identifier>DOI: 10.1007/s00192-012-1924-7</identifier><identifier>PMID: 22930215</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Administration, Intravenous ; Animals ; Benzilates - pharmacology ; Benzilates - therapeutic use ; Body Weight - drug effects ; Catecholamines - blood ; Drug Evaluation, Preclinical ; Female ; Gynecology ; Medicine ; Medicine & Public Health ; Muscarinic Antagonists - pharmacology ; Muscarinic Antagonists - therapeutic use ; Original Article ; Rats ; Rats, Sprague-Dawley ; Sneezing ; Urinary Incontinence - drug therapy ; Urology</subject><ispartof>International Urogynecology Journal, 2013-04, Vol.24 (4), p.683-688</ispartof><rights>The International Urogynecological Association 2012</rights><rights>The International Urogynecological Association 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-80f0267700d8a248c7c32b2dc8dc400914041e3fbbcb02154544efb667c0924f3</citedby><cites>FETCH-LOGICAL-c372t-80f0267700d8a248c7c32b2dc8dc400914041e3fbbcb02154544efb667c0924f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22930215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitta, Takeya</creatorcontrib><creatorcontrib>Tyagi, Vikas</creatorcontrib><creatorcontrib>Nanri, Masato</creatorcontrib><creatorcontrib>Kiniwa, Mamoru</creatorcontrib><creatorcontrib>Nonomura, Katsuya</creatorcontrib><creatorcontrib>Yoshimura, Naoki</creatorcontrib><title>Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats</title><title>International Urogynecology Journal</title><addtitle>Int Urogynecol J</addtitle><addtitle>Int Urogynecol J</addtitle><description>Introduction and hypothesis
Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats.
Methods
Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested.
Results
Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased.
Conclusions
Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance.</description><subject>Administration, Intravenous</subject><subject>Animals</subject><subject>Benzilates - pharmacology</subject><subject>Benzilates - therapeutic use</subject><subject>Body Weight - drug effects</subject><subject>Catecholamines - blood</subject><subject>Drug Evaluation, Preclinical</subject><subject>Female</subject><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Muscarinic Antagonists - therapeutic use</subject><subject>Original Article</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sneezing</subject><subject>Urinary Incontinence - drug therapy</subject><subject>Urology</subject><issn>0937-3462</issn><issn>1433-3023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kctq3TAQhkVpaU7TPkA3RdBNF3EyuhzLXpaQXiCQTbMWsjw-VrClU8ku5C36yB1z0lIKBcEI5pt_Lj9jbwVcCgBzVQBEKysQsqKoK_OM7YRWqlIg1XO2g1aZSulanrFXpTwAgIY9vGRnUraEiP2O_bwZBvRL4Wngx5yO4QfmEJGPj31OfpxSDj1ecBfpLcGPaaJsPgTP3QHjcsFT5GvGZcxu4j4REzF65DP60cVQ5kKFPT9OrsyOe7fgpuHmrQfhnjSyWwKphMjpV16zF4ObCr55iufs_tPNt-sv1e3d56_XH28rr4xcqgYGkLUxAH3jpG688Up2svdN7zVAKzRogWroOt9tm-q91jh0dW080KkGdc4-nHRp6-8rlsXOoXicJhcxrcUKJdpa1HQxQt__gz6kNUeabqOaVmtSJEqcKJ9TKRkHe8xhdvnRCrCbXfZklyW77GaXNVTz7kl57Wbs_1T89ocAeQIKpeIB81-t_6v6C2l1oaU</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Kitta, Takeya</creator><creator>Tyagi, Vikas</creator><creator>Nanri, Masato</creator><creator>Kiniwa, Mamoru</creator><creator>Nonomura, Katsuya</creator><creator>Yoshimura, Naoki</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats</title><author>Kitta, Takeya ; Tyagi, Vikas ; Nanri, Masato ; Kiniwa, Mamoru ; Nonomura, Katsuya ; Yoshimura, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-80f0267700d8a248c7c32b2dc8dc400914041e3fbbcb02154544efb667c0924f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Intravenous</topic><topic>Animals</topic><topic>Benzilates - pharmacology</topic><topic>Benzilates - therapeutic use</topic><topic>Body Weight - drug effects</topic><topic>Catecholamines - blood</topic><topic>Drug Evaluation, Preclinical</topic><topic>Female</topic><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Muscarinic Antagonists - therapeutic use</topic><topic>Original Article</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sneezing</topic><topic>Urinary Incontinence - drug therapy</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitta, Takeya</creatorcontrib><creatorcontrib>Tyagi, Vikas</creatorcontrib><creatorcontrib>Nanri, Masato</creatorcontrib><creatorcontrib>Kiniwa, Mamoru</creatorcontrib><creatorcontrib>Nonomura, Katsuya</creatorcontrib><creatorcontrib>Yoshimura, Naoki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International Urogynecology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitta, Takeya</au><au>Tyagi, Vikas</au><au>Nanri, Masato</au><au>Kiniwa, Mamoru</au><au>Nonomura, Katsuya</au><au>Yoshimura, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats</atitle><jtitle>International Urogynecology Journal</jtitle><stitle>Int Urogynecol J</stitle><addtitle>Int Urogynecol J</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>24</volume><issue>4</issue><spage>683</spage><epage>688</epage><pages>683-688</pages><issn>0937-3462</issn><eissn>1433-3023</eissn><abstract>Introduction and hypothesis
Anticholinergics are used to treat overactive bladder. Anticholinergic agents such as propiverine hydrochloride reportedly increase plasma catecholamine levels in rats. It is also known that active urethral closure mechanisms prevents stress urinary incontinence (SUI), which is enhanced by central and peripheral noradrenergic system activation. Therefore, we examined the influence of propiverine hydrochloride on urethral anti-incontinence function in rats.
Methods
Adult female rats were divided into propiverine and vehicle-treated groups. The propiverine group was given propiverine orally once a day for 2 weeks, after which urethral function and plasma concentrations of catecholamine (dopamine, norepinephrine, epinephrine) were tested.
Results
Urethral baseline pressure measured by a microtransducer-tipped urethral catheter and leak-point pressure during passive intravesical pressure elevation were significantly increased in the propiverine group compared with the vehicle group. Plasma norepinephrine and epinephrine levels in the propiverine group were also significantly increased.
Conclusions
Propiverine treatment that increases plasma catecholamine levels could contribute to improvement of SUI conditions by increasing urethral resistance.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>22930215</pmid><doi>10.1007/s00192-012-1924-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Intravenous Animals Benzilates - pharmacology Benzilates - therapeutic use Body Weight - drug effects Catecholamines - blood Drug Evaluation, Preclinical Female Gynecology Medicine Medicine & Public Health Muscarinic Antagonists - pharmacology Muscarinic Antagonists - therapeutic use Original Article Rats Rats, Sprague-Dawley Sneezing Urinary Incontinence - drug therapy Urology |
| title | Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats |
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