Rage Gene Polymorphism in Heart Failure Patients with and without Angiographic Evidence of Significant Coronary Atherosclerosis

Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogene...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2013-01, Vol.26 (1), p.199-206
Main Authors: Falcone, C., Bozzini, S., Matrone, B., Colonna, A., Falcone, R., Calcagnino, M., Pelissero, G.
Format: Article
Language:English
Subjects:
Aged
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - genetics
Female
Heart Failure - diagnostic imaging
Heart Failure - genetics
Humans
Male
Middle Aged
Polymorphism, Genetic
Receptor for Advanced Glycation End Products
Receptors, Immunologic - genetics
Citations: Items that this one cites
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Summary:Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)
ISSN:0394-6320
2058-7384
DOI:10.1177/039463201302600119