Resistance to high-maintenance dose of prasugrel treated by ticagrelor: A case report

We describe a case of a 34-year-old woman with chronic renal failure under haemodialysis. The patient exhibited high on-treatment platelet reactivity to gradually stronger thienopyridine regimens, including standard and high maintenance doses of prasugrel. Platelet function was monitored by VerifyNo...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2013-01, Vol.24 (3), p.239-241
Main Authors: Xanthopoulou, Ioanna, Stavrou, Eleana F., Kassimis, George, Goudas, Pavlos, Alexopoulos, Dimitrios
Format: Article
Language:English
Subjects:
Adenosine - administration & dosage
Adenosine - analogs & derivatives
Adenosine - therapeutic use
Adult
Drug Resistance - genetics
Female
Humans
Kidney Failure, Chronic - therapy
Piperazines - administration & dosage
Piperazines - therapeutic use
Platelet Activation - drug effects
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - therapeutic use
Prasugrel Hydrochloride
Purinergic P2Y Receptor Antagonists - therapeutic use
Receptors, Purinergic P2Y - genetics
Renal Dialysis
Thiophenes - administration & dosage
Thiophenes - therapeutic use
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Summary:We describe a case of a 34-year-old woman with chronic renal failure under haemodialysis. The patient exhibited high on-treatment platelet reactivity to gradually stronger thienopyridine regimens, including standard and high maintenance doses of prasugrel. Platelet function was monitored by VerifyNow assay and genotyping for various single-nucleotide polymorphisms was performed. Treatment with ticagrelor 180 mg/day was effective in reducing the platelet reactivity.
ISSN:0953-7104
1369-1635
DOI:10.3109/09537104.2012.682104