Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma

Current therapy of malignant glioma in clinic is unsatisfactory with poor patient compliance due to low therapeutic efficiency and strong systemic side effects. Herein, we combined chemo-photothermal targeted therapy of glioma within one novel multifunctional drug delivery system. A targeting peptid...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2013-03, Vol.135 (12), p.4799-4804
Main Authors: Wang, Yi, Wang, Kaiyuan, Zhao, Jianfeng, Liu, Xingang, Bu, Juan, Yan, Xueying, Huang, Rongqin
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - pharmacology
Brain - drug effects
Brain - pathology
Brain Neoplasms - drug therapy
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cell Line, Tumor
Delayed-Action Preparations - chemistry
Doxorubicin - administration & dosage
Doxorubicin - pharmacology
Drug Delivery Systems - methods
Glioma - drug therapy
Glioma - pathology
Glioma - therapy
Graphite - chemistry
Humans
Hyperthermia, Induced
Nanostructures - chemistry
Photochemical Processes
Photochemotherapy
Protons
Silicon Dioxide - chemistry
Temperature
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Summary:Current therapy of malignant glioma in clinic is unsatisfactory with poor patient compliance due to low therapeutic efficiency and strong systemic side effects. Herein, we combined chemo-photothermal targeted therapy of glioma within one novel multifunctional drug delivery system. A targeting peptide (IP)-modified mesoporous silica-coated graphene nanosheet (GSPI) was successfully synthesized and characterized, and first introduced to the drug delivery field. A doxorubicin (DOX)-loaded GSPI-based system (GSPID) showed heat-stimulative, pH-responsive, and sustained release properties. Cytotoxicity experiments demonstrated that combined therapy mediated the highest rate of death of glioma cells compared to that of single chemotherapy or photothermal therapy. Furthermore, the IP modification could significantly enhance the accumulation of GSPID within glioma cells. These findings provided an excellent drug delivery system for combined therapy of glioma due to the advanced chemo-photothermal synergistic targeted therapy and good drug release properties of GSPID, which could effectively avoid frequent and invasive dosing and improve patient compliance.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja312221g