Expression of OV-6 in primary colorectal cancer and rectal cancer with preoperative chemoradiotherapy: a clinicopathological study

Aims OV‐6 is among the best available markers of liver stem cells. The aim of this study was to investigate OV‐6 expression and its clinical implications in colorectal cancer. Methods and results Expression of OV‐6 and its clinical implications were investigated in 94 patients with American Joint Co...

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Published in:Histopathology 2013-04, Vol.62 (5), p.742-751
Main Authors: Lin, Chih-Hung, Liu, Chia-Hsing, Tsai, Hsiang-Lin, Wang, Jaw-Yuan, Tsai, Hung-Pei, Chai, Chee-Yin
Format: Article
Language:English
Subjects:
Aged
Antigens, Differentiation - metabolism
Biomarkers, Tumor - metabolism
Chemoradiotherapy, Adjuvant - methods
colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Female
hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Male
Neoplasm Staging
OV-6
rectal cancer
Rectal Neoplasms - metabolism
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Retrospective Studies
Survival Rate
Taiwan - epidemiology
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Summary:Aims OV‐6 is among the best available markers of liver stem cells. The aim of this study was to investigate OV‐6 expression and its clinical implications in colorectal cancer. Methods and results Expression of OV‐6 and its clinical implications were investigated in 94 patients with American Joint Committee on Cancer (AJCC) stage I–III primary colorectal cancer and in 37 rectal cancer patients who had received preoperative chemoradiotherapy. The two main expression patterns of OV‐6 were cytoplasmic and membranous. Overexpression of OV‐6, which was identified on the basis of overall staining intensity, was associated with perineural invasion, lymphovascular invasion, and early relapses. Membranous OV‐6 overexpression was also significantly associated with depth of tumour invasion, AJCC stage, lymphovascular and perineural invasion, and postoperative early relapse. Disease‐free survival and overall survival were significantly poorer in patients with high overall OV‐6 expression than in those with low overall OV‐6 expression (P = 0.015 and P = 0.029, respectively), and significantly poorer in patients with high membranous OV‐6 expression than in those with low membranous OV‐6 expression (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12075