Brugada syndrome

As a clinical entity the Brugada syndrome has existed since 1992 and has been associated with a high risk of sudden cardiac death predominately in younger males. Patients can present with symptoms (ie syncope, palpitations, aborted sudden cardiac death) and asymptomatically. Its three characteristic...

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Bibliographic Details
Published in:Hong Kong medical journal = Xianggang yi xue za zhi 2013-04, Vol.19 (2), p.159-167
Main Authors: Jellins, Jessica, Milanovic, Mitchell, Taitz, David-Joel, Wan, S H, Yam, P W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Brugada Syndrome - diagnosis
Brugada Syndrome - genetics
Brugada Syndrome - mortality
Brugada Syndrome - therapy
Death, Sudden, Cardiac - epidemiology
Defibrillators, Implantable
Electrocardiography - methods
Female
Genetic Predisposition to Disease - epidemiology
Hong Kong
Humans
Male
Middle Aged
Prognosis
Risk Assessment
Severity of Illness Index
Sex Factors
Sodium Channel Blockers
Survival Rate
Treatment Outcome
Young Adult
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Summary:As a clinical entity the Brugada syndrome has existed since 1992 and has been associated with a high risk of sudden cardiac death predominately in younger males. Patients can present with symptoms (ie syncope, palpitations, aborted sudden cardiac death) and asymptomatically. Its three characteristic electrocardiographic patterns can occur both spontaneously or after provocation with sodium channel-blocking agents. Risk stratification and the need for treatment depend on the patient's symptoms, electrocardiography, family history, and electrophysiological inducibility to discern if treatment by implantable cardioverter defibrillator, the only effective treatment to date, is appropriate. This review focuses on Brugada syndrome and various aspects of the disease including proposed mechanisms, epidemiology, clinical presentations, genetics, diagnosis, risk stratification, and treatment options.
ISSN:1024-2708
2226-8707