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pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors
Solution-gated reduced graphene oxide field-effect transistors (R-GO FETs) were investigated for pH sensing and biochemical sensing applications. A channel of a networked R-GO film formed by self-assembly was incorporated as a sensing layer into a solution-gated FET structure for pH sensing and the...
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Published in: | Biosensors & bioelectronics 2013-07, Vol.45, p.70-76 |
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description | Solution-gated reduced graphene oxide field-effect transistors (R-GO FETs) were investigated for pH sensing and biochemical sensing applications. A channel of a networked R-GO film formed by self-assembly was incorporated as a sensing layer into a solution-gated FET structure for pH sensing and the detection of acetylcholine (Ach), which is a neurotransmitter in the nerve system, through enzymatic reactions. The fabricated R-GO FET was sensitive to protons (H+) with a pH sensitivity of 29mV/pH in terms of the shift of the charge neutrality point (CNP), which is attributed to changes in the surface potential caused by the interaction of protons with OH surface functional groups present on the R-GO surface. The R-GO FET immobilized with acetylcholinesterase (AchE) was used to detect Ach in the concentration range of 0.1–10mM by sensing protons generated during the enzymatic reactions. The results indicate that R-GO FETs provide the capability to detect protons, demonstrating their applicability as a biosensing device for enzymatic reactions.
► R-GO FETs are investigated for pH sensing and biochemical sensing applications. ► pH sensing using R-GO FET shows Nernstian behavior and good reversibility. ► The pH sensing mechanism can be presumably explained by the site binding theory. ► The R-GO FET is applied for detection of acetylcholine based on its pH sensitivity. |
doi_str_mv | 10.1016/j.bios.2013.01.051 |
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► R-GO FETs are investigated for pH sensing and biochemical sensing applications. ► pH sensing using R-GO FET shows Nernstian behavior and good reversibility. ► The pH sensing mechanism can be presumably explained by the site binding theory. ► The R-GO FET is applied for detection of acetylcholine based on its pH sensitivity.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2013.01.051</identifier><identifier>PMID: 23454740</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Acetylcholine ; Acetylcholinesterase - chemistry ; Biological and medical sciences ; Biosensing Techniques ; Biosensors ; Biotechnology ; Field effect transistor ; Fundamental and applied biological sciences. Psychology ; Graphite - chemistry ; Hydrogen-Ion Concentration ; Methods. Procedures. Technologies ; Nanotechnology ; Oxides - chemistry ; pH sensor ; Reduced graphene oxide ; Solutions - chemistry ; Transistors, Electronic ; Various methods and equipments</subject><ispartof>Biosensors & bioelectronics, 2013-07, Vol.45, p.70-76</ispartof><rights>2013 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-8aab5ec1c049f54adae7b05f8d55db6989291112f94e019bdce73e966d95d79a3</citedby><cites>FETCH-LOGICAL-c489t-8aab5ec1c049f54adae7b05f8d55db6989291112f94e019bdce73e966d95d79a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27239129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23454740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sohn, Il-Yung</creatorcontrib><creatorcontrib>Kim, Duck-Jin</creatorcontrib><creatorcontrib>Jung, Jin-Heak</creatorcontrib><creatorcontrib>Yoon, Ok Ja</creatorcontrib><creatorcontrib>Nguyen Thanh, Tien</creatorcontrib><creatorcontrib>Tran Quang, Trung</creatorcontrib><creatorcontrib>Lee, Nae-Eung</creatorcontrib><title>pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>Solution-gated reduced graphene oxide field-effect transistors (R-GO FETs) were investigated for pH sensing and biochemical sensing applications. A channel of a networked R-GO film formed by self-assembly was incorporated as a sensing layer into a solution-gated FET structure for pH sensing and the detection of acetylcholine (Ach), which is a neurotransmitter in the nerve system, through enzymatic reactions. The fabricated R-GO FET was sensitive to protons (H+) with a pH sensitivity of 29mV/pH in terms of the shift of the charge neutrality point (CNP), which is attributed to changes in the surface potential caused by the interaction of protons with OH surface functional groups present on the R-GO surface. The R-GO FET immobilized with acetylcholinesterase (AchE) was used to detect Ach in the concentration range of 0.1–10mM by sensing protons generated during the enzymatic reactions. The results indicate that R-GO FETs provide the capability to detect protons, demonstrating their applicability as a biosensing device for enzymatic reactions.
► R-GO FETs are investigated for pH sensing and biochemical sensing applications. ► pH sensing using R-GO FET shows Nernstian behavior and good reversibility. ► The pH sensing mechanism can be presumably explained by the site binding theory. ► The R-GO FET is applied for detection of acetylcholine based on its pH sensitivity.</description><subject>Acetylcholine</subject><subject>Acetylcholinesterase - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biosensing Techniques</subject><subject>Biosensors</subject><subject>Biotechnology</subject><subject>Field effect transistor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Graphite - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Methods. Procedures. Technologies</subject><subject>Nanotechnology</subject><subject>Oxides - chemistry</subject><subject>pH sensor</subject><subject>Reduced graphene oxide</subject><subject>Solutions - chemistry</subject><subject>Transistors, Electronic</subject><subject>Various methods and equipments</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi1ERZfCH-CAfEHikuCPOIklLqgCilSJS3u2HHu89SobB08C5d_X0S5w4zQjzTPvjB5C3nBWc8bbD4d6iAlrwbisGa-Z4s_IjvedrBoh1XOyY1q1lWpbeUleIh4YYx3X7AW5FLJRTdewHfk131CECeO0p-7BZusWyBGX6JDaydPtwnls53mMzi4xTTQFimlct77a2wU8zeBXV-o-2_kBJqDpMXqgIcLoKwgB3EKXbEsULinjK3IR7Ijw-lyvyP2Xz3fXN9Xt96_frj_dVq7p9VL11g4KHHes0UE11lvoBqZC75XyQ6t7LTTnXATdAON68A46CbptvVa-01Zekfen3DmnHyvgYo4RHYyjnSCtaLgUohO6U7Kg4oS6nBAzBDPneLT5t-HMbMLNwWw6zCbcMG6K8LL09py_Dkfwf1f-GC7AuzNg0dkxFAUu4j-uE1JzoQv38cRBsfEzQjboIkxFaczFnfEp_u-PJ6TYoZk</recordid><startdate>20130715</startdate><enddate>20130715</enddate><creator>Sohn, Il-Yung</creator><creator>Kim, Duck-Jin</creator><creator>Jung, Jin-Heak</creator><creator>Yoon, Ok Ja</creator><creator>Nguyen Thanh, Tien</creator><creator>Tran Quang, Trung</creator><creator>Lee, Nae-Eung</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130715</creationdate><title>pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors</title><author>Sohn, Il-Yung ; Kim, Duck-Jin ; Jung, Jin-Heak ; Yoon, Ok Ja ; Nguyen Thanh, Tien ; Tran Quang, Trung ; Lee, Nae-Eung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-8aab5ec1c049f54adae7b05f8d55db6989291112f94e019bdce73e966d95d79a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcholine</topic><topic>Acetylcholinesterase - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biosensing Techniques</topic><topic>Biosensors</topic><topic>Biotechnology</topic><topic>Field effect transistor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Graphite - chemistry</topic><topic>Hydrogen-Ion Concentration</topic><topic>Methods. Procedures. Technologies</topic><topic>Nanotechnology</topic><topic>Oxides - chemistry</topic><topic>pH sensor</topic><topic>Reduced graphene oxide</topic><topic>Solutions - chemistry</topic><topic>Transistors, Electronic</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohn, Il-Yung</creatorcontrib><creatorcontrib>Kim, Duck-Jin</creatorcontrib><creatorcontrib>Jung, Jin-Heak</creatorcontrib><creatorcontrib>Yoon, Ok Ja</creatorcontrib><creatorcontrib>Nguyen Thanh, Tien</creatorcontrib><creatorcontrib>Tran Quang, Trung</creatorcontrib><creatorcontrib>Lee, Nae-Eung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohn, Il-Yung</au><au>Kim, Duck-Jin</au><au>Jung, Jin-Heak</au><au>Yoon, Ok Ja</au><au>Nguyen Thanh, Tien</au><au>Tran Quang, Trung</au><au>Lee, Nae-Eung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2013-07-15</date><risdate>2013</risdate><volume>45</volume><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>Solution-gated reduced graphene oxide field-effect transistors (R-GO FETs) were investigated for pH sensing and biochemical sensing applications. A channel of a networked R-GO film formed by self-assembly was incorporated as a sensing layer into a solution-gated FET structure for pH sensing and the detection of acetylcholine (Ach), which is a neurotransmitter in the nerve system, through enzymatic reactions. The fabricated R-GO FET was sensitive to protons (H+) with a pH sensitivity of 29mV/pH in terms of the shift of the charge neutrality point (CNP), which is attributed to changes in the surface potential caused by the interaction of protons with OH surface functional groups present on the R-GO surface. The R-GO FET immobilized with acetylcholinesterase (AchE) was used to detect Ach in the concentration range of 0.1–10mM by sensing protons generated during the enzymatic reactions. The results indicate that R-GO FETs provide the capability to detect protons, demonstrating their applicability as a biosensing device for enzymatic reactions.
► R-GO FETs are investigated for pH sensing and biochemical sensing applications. ► pH sensing using R-GO FET shows Nernstian behavior and good reversibility. ► The pH sensing mechanism can be presumably explained by the site binding theory. ► The R-GO FET is applied for detection of acetylcholine based on its pH sensitivity.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>23454740</pmid><doi>10.1016/j.bios.2013.01.051</doi><tpages>7</tpages></addata></record> |
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subjects | Acetylcholine Acetylcholinesterase - chemistry Biological and medical sciences Biosensing Techniques Biosensors Biotechnology Field effect transistor Fundamental and applied biological sciences. Psychology Graphite - chemistry Hydrogen-Ion Concentration Methods. Procedures. Technologies Nanotechnology Oxides - chemistry pH sensor Reduced graphene oxide Solutions - chemistry Transistors, Electronic Various methods and equipments |
title | pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors |
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