Lessons from the Cancer Genome

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein...

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Bibliographic Details
Published in:Cell 2013-03, Vol.153 (1), p.17-37
Main Authors: Garraway, Levi A., Lander, Eric S.
Format: Article
Language:English
Subjects:
Animals
Genes, Neoplasm
Genome, Human
Genomics - methods
Humans
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - therapy
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Summary:Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.03.002