Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes

• Published in: Diabetes research and clinical practice 2013-02, Vol.99 (2), p.145-150
• Main Authors: Izumi, Yoshio, Yabe, Daisuke, Taniguchi, Ataru, Fukushima, Mitsuo, Nakai, Yoshikatsu, Hosokawa, Masaya, Okumura, Takahide, Nin, Kazuko, Matsumoto, Kazunari, Nishimura, Fusanori, Nagasaka, Shoichiro, Seino, Yutaka
• Format: Article
• Language: English
• Subjects: Adiponectin - blood; Aged; Asian Continental Ancestry Group; Creatinine - blood; Diabetes Mellitus, Type 2 - blood; eGFR; Endocrinology & Metabolism; Female; Glomerular Filtration Rate - physiology; Humans; Leptin - blood; Male; Middle Aged; Obesity - blood; Receptors, Tumor Necrosis Factor - blood; Renal Insufficiency, Chronic - blood; Tumor necrosis factor; Type 2 diabetes
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2012.11.002

Abstract Aims Chronic low-grade inflammation and/or obesity are suggested to induce chronic kidney disease (CKD) in patients with type 2 diabetes. This cross-sectional study was performed to investigate the relationship between inflammatory biomarkers and CKD in non-obese patients with type 2 diabetes. Methods 106 non-obese Japanese patients with type 2 diabetes were recruited for the measurement of GFR, TNF, HMW adiponectin, leptin, hsCRP and some variables including urinary albumin. BMI, serum creatinine, and urinary albumin levels were 22.2 ± 0.2 kg/m2 (17.1–24.9 kg/m2 ), 0.76 ± 0.02 mg/dl (0.39–1.38 mg/dl), 40.4 ± 4.3 mg/gCr (1.6–195.0 mg/gCr), respectively. They were stratified into two groups based on the value of eGFR: low eGFR (eGFR < 60 ml/min/1.73 m2 ) and normal eGFR (eGFR > 60 ml/min/1.73 m2 ). Logistic regression analysis was used for statistical analysis. Results Whereas univariate logistic regression analysis showed that gender, diabetes duration, triglyceride, HDL cholesterol, uric acid, urinary albumin, and soluble TNF receptors (sTNF-R1, sTNF-R2) are associated with the development of stage 3 CKD, multivariate logistic regression analysis revealed that sTNF-R2 (Odds ratio 1.003, 95% confidence interval 1.000 to 1.005, P = 0.030) showed significant associations with the development of stage 3 CKD. Conclusions Circulating TNF receptor 2 is an independent risk factor for CKD in non-obese Japanese patients with type 2 diabetes.