Acute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokines

A total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs....

Full description

Saved in:
Bibliographic Details
Published in:Fish & shellfish immunology 2013-05, Vol.34 (5), p.1057-1062
Main Authors: Claudiano, Gustavo da Silva, Petrillo, Thalita R., Manrique, Wilson G., Castro, Marcello P., Loureiro, Bruna A., Marcusso, Paulo F., Belo, Marco A.A., Moraes, Julieta R.E., de Moraes, Flávio Ruas
Format: Article
Language:English
Subjects:
Aeromonas hydrophila - immunology
Animals
Anti-Inflammatory Agents - administration & dosage
Bacterial Vaccines - administration & dosage
Capillary Permeability
Cellular Structures
Characidae - immunology
Characidae - microbiology
Chemical mediators
Cytokines - metabolism
Dexamethasone - administration & dosage
Dose-Response Relationship, Drug
Eicosanoids - metabolism
Evans blue
Gram-Negative Bacterial Infections - immunology
Gram-Negative Bacterial Infections - metabolism
Gram-Negative Bacterial Infections - veterinary
Indomethacin - administration & dosage
Inflammation
Teleost
Thiazines - administration & dosage
Thiazoles - administration & dosage
Time Factors
Vaccines, Inactivated - administration & dosage
Vascular alteration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs. It was observed that after inoculation of A. hydrophila, the maximum VP occurred 180 min post-stimulus (MPS). Pretreatment with anti-inflammatory drugs inhibited VP, and the inhibitory effect of dexamethasone was seen earlier than the effects caused by meloxicam and indomethacin. Inoculation of the bacterium caused a gradual increase in the accumulation of cells, which reached a maximum 24 h post-stimulus (HPS). Pretreatment with dexamethasone, indomethacin and meloxicam reduced the accumulation of lymphocytes, thrombocytes, granulocytes and macrophages. There was no significant difference between the different doses of the drugs tested. The results suggest that eicosanoids and pro-inflammatory cytokines participate in chemical mediation in acute inflammation in pacus.
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2013.01.006