Sugar expression in the mucosae of the canine uterus and vagina during the oestrous cycle and with pyometra

The pathogenesis of canine pyometra is still unclear, but bacterial infection of the endometrium, mediated by bacterial lectins, is suspected to induce pyometra. The aim of this study was to investigate sugar expression in the mucosae of the uterus and vagina of healthy dogs with normal oestrous cyc...

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Bibliographic Details
Published in:The veterinary journal (1997) 2013-04, Vol.196 (1), p.116-118
Main Authors: Yasunaga, Y., Takeuchi, T., Shimokawa, T., Asano, A., Nabeta, M., Ohta, Y.
Format: Article
Language:English
Subjects:
Animals
Bitch
Carbohydrate Metabolism
diestrus
Dog Diseases - metabolism
Dog Diseases - microbiology
Dogs
endometrium
Estrous Cycle
Female
glucose
Lectins
Lectins - metabolism
mannose
Mucous Membrane - metabolism
pathogenesis
pathogens
Pyometra
Pyometra - metabolism
Pyometra - microbiology
Pyometra - veterinary
Sugars
temporal variation
Uterus
Uterus - metabolism
Vagina - metabolism
vaginal mucosa
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Summary:The pathogenesis of canine pyometra is still unclear, but bacterial infection of the endometrium, mediated by bacterial lectins, is suspected to induce pyometra. The aim of this study was to investigate sugar expression in the mucosae of the uterus and vagina of healthy dogs with normal oestrous cycles and in dogs with pyometra, using a panel of lectins to investigate the pathogenesis of pyometra. In dogs with pyometra, the uterine and vaginal mucosae were positive for lectins that selectively bind to glucose or mannose, especially during days 7–10 and 30–40 of dioestrus. These results suggest that temporal changes in sugar expression in the uterus and vagina present an opportunity for pathogens to infect the endometrium, causing pyometra.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2012.08.008