Effects of thyroxin therapy on different analytes related to obesity and inflammation in dogs with hypothyroidism

• Published in: The veterinary journal (1997) 2013-04, Vol.196 (1), p.71-75
• Main Authors: Tvarijonaviciute, A., Jaillardon, L., Cerón, J.J., Siliart, B.
• Format: Article
• Language: English
• Subjects: Acute-Phase Proteins - metabolism; Adipokines - blood; Adiponectin; amyloid; Animals; Biomarkers - blood; Biomarkers - metabolism; blood serum; Butyrylcholinesterase; Butyrylcholinesterase - blood; C-reactive protein; Colorimetry - veterinary; Dog; Dog Diseases - drug therapy; Dogs; Female; haptoglobins; Hypothyroidism; Hypothyroidism - drug therapy; Hypothyroidism - veterinary; Immunoassay - veterinary; inflammation; Inflammation - drug therapy; Inflammation - etiology; Inflammation - veterinary; insulin resistance; Leptin; Male; metabolism; obesity; Obesity - drug therapy; Obesity - etiology; Obesity - veterinary; therapeutics; thyroxine; Thyroxine - therapeutic use
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2012.08.005

Hypothyroidism in dogs is accompanied by changes in intermediary metabolism including alterations in bodyweight (BW), insulin resistance, and lipid profile. In this study, changes in selected adipokines (adiponectin, leptin), butyrylcholinesterase (BChE), and acute phase proteins, including C-reactive protein, haptoglobin (Hp) and serum amyloid A (SAA), were studied in dogs with hypothyroidism under thyroxin therapy. Blood samples were collected when hypothyroidism was diagnosed (before treatment) and after treatment with thyroxin. Twenty-eight of 39 dogs exhibited a good therapeutic response (group A), whereas the remainder were considered to have been insufficiently treated (group B). Following treatment, group A dogs demonstrated a statistically significant decrease in canine thyroid stimulating hormone (c-TSH) (P