Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients

Background and aim Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxi...

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Bibliographic Details
Published in:Supportive care in cancer 2013-05, Vol.21 (5), p.1359-1363
Main Authors: Fuchs-Tarlovsky, Vanessa, Rivera, María Amanda Casillas, Altamirano, Karolina Alvarez, Lopez-Alvarenga, Juan Carlos, Ceballos-Reyes, Guillermo Manuel
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
Antioxidants
Antioxidants - pharmacology
Biometry
Cancer
Cancer patients
Chemoradiotherapy - methods
Chemotherapy
Cisplatin - therapeutic use
Drug therapy
Female
Hematologic Diseases - drug therapy
Hematologic Diseases - etiology
Hemoglobin
Hemoglobins - metabolism
Humans
Malondialdehyde - blood
Medicine
Medicine & Public Health
Middle Aged
Nursing
Nursing Research
Oncology
Original Article
Oxidative stress
Oxidative Stress - drug effects
Pain Medicine
Prospective Studies
Quality of Life
Rehabilitation Medicine
Single-Blind Method
Surveys and Questionnaires
Uterine Cervical Neoplasms - therapy
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Summary:Background and aim Hematological toxicity and oxidative stress are common in cancer patients. Antioxidant supplementation has been shown to decrease oxidative stress, but there is still controversy on this topic. The aim of this study was to determine the effect of antioxidant supplementation on oxidative stress, hematological toxicity, and quality of life (QoL) in cervical cancer patients. Methods Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement. Plasma concentrations of malondialdehyde, free carbonyls, and blood biometry were measured. EORTC quality of life questionnaire was applied before and after oncology treatment. Student’s t test for independent samples and X 2 for categorical variables were performed. Results One hundred three patients were randomly assigned to receive treatment with antioxidants 49 (48 %) or placebo 54 (52.40 %). At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group ( p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-012-1674-6