Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits

To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a si...

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Bibliographic Details
Published in:Optics letters 2012-12, Vol.37 (23), p.4841-4843
Main Authors: Zorzos, Anthony N, Scholvin, Jorg, Boyden, Edward S, Fonstad, Clifton G
Format: Article
Language:English
Subjects:
Arrays
Brain
Circuits
Light
Nerve Net
Neurons
Optical Devices
Optical fibers
Prostheses and Implants
Proteins
Silence
Three dimensional
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Summary:To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain.
ISSN:0146-9592
1539-4794
DOI:10.1364/OL.37.004841