Siderophore conjugates

There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins. Among the sy...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2013-01, Vol.1277 (1), p.115-126
Main Author: Page, Malcolm G. P.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Antibiotics
Bacteria
Bacteriology
BAL30072
Barriers
beta-Lactams - chemistry
Conjugates
Glycopeptides
Humans
iron transport
Membranes
Nucleosides
Permeability
sideromycin
siderophore antibiotics
Siderophores - chemistry
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Summary:There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins. Among the synthetic analogues that have been investigated are conjugates of nucleosides, glycopeptides, macrolides, fluroquinolones, and, above all, β‐lactams. Despite this effort, few compounds have progressed beyond experimental studies. One compound, the siderophore monosulfactam BAL30072, is in early clinical studies.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12024