Protein-Directed In Situ Synthesis of Gold Nanoparticles on Reduced Graphene Oxide Modified Electrode for Nonenzymatic Glucose Sensing

A novel nonenzymatic glucose sensor was developed based on well‐dispersed gold nanoparticles, which were in situ grown under direction of protein on a reduced graphene oxide modified electrode. This electrode exhibited high electrocatalytic activity towards glucose oxidation without use of any enzym...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2012-12, Vol.24 (12), p.2348-2353
Main Authors: Liu, Yang, Dong, Yongqiang, Guo, Chun Xian, Cui, Zhiming, Zheng, Lianxi, Li, Chang Ming
Format: Article
Language:English
Subjects:
Electrodes
Glucose
Gold
Gold nanoparticles
Graphene
Mathematical analysis
Nanoparticles
Nonenzymatic sensors
Oxides
Proteins
Reduced graphene oxide
Sensors
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Summary:A novel nonenzymatic glucose sensor was developed based on well‐dispersed gold nanoparticles, which were in situ grown under direction of protein on a reduced graphene oxide modified electrode. This electrode exhibited high electrocatalytic activity towards glucose oxidation without use of any enzyme or mediator. In application for the amperometric detection of glucose, a wide linear range of 0.02–16.6 mM, low detection limit of 5 µM and good selectivity were obtained. The attractive analytical performances of the proposed glucose sensor, coupled with the facile preparation method, provide a promising electrochemical platform for the development of effective nonenzymatic sensors.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201200472