In depth analysis of the in vivotoxicity of nanoparticles of porous iron(iii) metal-organic frameworks

In vivoacute toxicity of high doses of nanoparticles of three different porous iron(iii) carboxylate Metal-Organic Frameworks(nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2013-03, Vol.4 (4), p.1597-1607
Main Authors: Baati, Tarek, Njim, Leila, Neffati, Fadoua, Kerkeni, Abdelhamid, Bouttemi, Muriel, Gref, Ruxandra, Najjar, Mohamed Fadhel, Zakhama, Abdelfateh, Couvreur, Patrick, Serre, Christian, Horcajada, Patricia
Format: Article
Language:English
Subjects:
Excretion
Metal-organic frameworks
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Rats
Toxicity
Urine
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Summary:In vivoacute toxicity of high doses of nanoparticles of three different porous iron(iii) carboxylate Metal-Organic Frameworks(nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.
ISSN:2041-6520
2041-6539
DOI:10.1039/c3sc22116d