Effects of Low-Dose Atorvastatin on Arterial Stiffness and Central Aortic Pressure Augmentation in Patients With Hypertension and Hypercholesterolemia

BACKGROUND Experimental and clinical data suggest that statins exert anti-inflammatory and antiproliferative actions on vasculature beyond their lipid-lowering properties. Whether these pleiotropic effects of statins translate into a beneficial effect on arterial stiffness is not clear. This study a...

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Bibliographic Details
Published in:American journal of hypertension 2013-05, Vol.26 (5), p.608-616
Main Authors: Kanaki, Aggeliki I., Sarafidis, Pantelis A., Georgianos, Panagiotis I., Kanavos, Konstantinos, Tziolas, Ioannis M., Zebekakis, Pantelis E., Lasaridis, Anastasios N.
Format: Article
Language:English
Subjects:
Aged
Anticholesteremic Agents - pharmacology
Anticholesteremic Agents - therapeutic use
Aorta - drug effects
Aorta - physiopathology
Atorvastatin Calcium
Blood Pressure - drug effects
Blood Pressure - physiology
Comorbidity
Dose-Response Relationship, Drug
Double-Blind Method
Female
Hemodynamics - drug effects
Hemodynamics - physiology
Heptanoic Acids - pharmacology
Heptanoic Acids - therapeutic use
Humans
Hypercholesterolemia - drug therapy
Hypercholesterolemia - epidemiology
Hypercholesterolemia - physiopathology
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Male
Middle Aged
Pulse Wave Analysis
Pyrroles - pharmacology
Pyrroles - therapeutic use
Treatment Outcome
Vascular Stiffness - drug effects
Vascular Stiffness - physiology
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Summary:BACKGROUND Experimental and clinical data suggest that statins exert anti-inflammatory and antiproliferative actions on vasculature beyond their lipid-lowering properties. Whether these pleiotropic effects of statins translate into a beneficial effect on arterial stiffness is not clear. This study aimed to evaluate the potential effects of low-dose atorvastatin treatment on arterial stiffness and central arterial pressure waveforms in patients with mild hypertension and hypercholesterolemia. METHODS In a double-blind, randomized, placebo-controlled fashion, 50 hypertensive and hypercholesterolemic patients were allocated to receive 10mg of atorvastatin or placebo for 26 weeks. Arterial stiffness was assessed by aortic pulse-wave velocity (PWV) using a Sphygmocor device. Central arterial pressure waveform parameters were estimated by radial artery applanation tonometry. Heart rate-adjusted augmentation index (AIx(75)) was used as measure of wave reflections. RESULTS At study end, aortic PWV (9.0±1.5 vs. 10.9±2.6 m/sec; P
ISSN:0895-7061
1941-7225
DOI:10.1093/ajh/hps098