Inhibitory Effects of Prior Low-dose X-irradiation on Ischemia-reperfusion Injury in Mouse Paw

We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ische...

Full description

Saved in:
Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 2007, Vol.48 (6), p.505-513
Main Authors: Kataoka, Takahiro, Mizuguchi, Yuko, Yoshimoto, Masaaki, Taguchi, Takehito, Yamaoka, Kiyonori
Format: Article
Language:English
Subjects:
Analysis
Animals
Dose-Response Relationship, Radiation
Edema
Female
Foot Diseases - pathology
Foot Diseases - physiopathology
Foot Diseases - prevention & control
Foot Diseases - radiotherapy
Injuries
Ionizing radiation
Ischemia
Leg
Mice
Mice, Inbred BALB C
Radiotherapy Dosage
Reactive oxygen species
Reperfusion
Reperfusion injury
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Reperfusion Injury - prevention & control
Reperfusion Injury - radiotherapy
Rubber
Superoxide dismutase
X radiation
X-Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
ISSN:0449-3060
1349-9157
1349-9157
DOI:10.1269/jrr.07060