Variability of the Biological Activity of Oxidized Titanium Implants

• Published in: Bulletin of experimental biology and medicine 2012-02, Vol.152 (4), p.475-479
• Main Authors: Shakhov, V. P., Vereschagin, V. I., Petrovskaya, T. S., Ignatov, V. P., Krylatov, A. V.
• Format: Article
• Language: English
• Subjects: Aluminum; Aluminum Oxide - chemistry; Animals; Biomedical and Life Sciences; Biomedicine; Bone implants; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Cell Biology; Cell Count; Cell Survival - drug effects; Cells, Cultured; Coated Materials, Biocompatible - chemical synthesis; Coated Materials, Biocompatible - pharmacology; Coatings; Dental Implants; Dermatologic Surgical Procedures; Internal Medicine; Laboratory Medicine; Materials Testing; Mesenchyme; Mice; Microscopy, Electron, Scanning; Nanotechnologies; Osseointegration - physiology; Osteogenesis; oxides; Pathology; Phosphates; Phosphorus; Phosphorus Compounds - chemistry; Pores; Porosity; Radicals; Skin - drug effects; Skin - ultrastructure; Subcutaneous Tissue - drug effects; Subcutaneous Tissue - surgery; Subcutaneous Tissue - ultrastructure; Surface Properties; Titanium; Titanium - chemistry; Titanium - pharmacology; zinc oxide; Zinc Oxide - chemistry
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1556-4

Oxidized titanium is a biologically inert material, but bioinertness reduces biomechanical characteristics of titanium implants. Modification of the structure of oxide surface layer of BT 5-1 titanium by increasing its thickness (by 1.7 times) and pore diameter (by 1.4 times) and by adding phosphorus, aluminum, and zinc oxides to its composition leads to radical modification of its biological characteristics. These implants acquire osteoinductive properties in in vivo systems not found in pure or oxidized BT 1-00 titanium and fairly well maintain in vitro growth of mesenchymal cells.