beta 1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer

Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. beta 1-integrins repre...

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Bibliographic Details
Published in:Breast cancer research : BCR 2011-11, Vol.13 (6), p.229-229
Main Authors: Lahlou, Hicham, Muller, William J
Format: Article
Language:English
Online Access:Get full text
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Summary:Consistent with their essential role in cell adhesion to the extracellular matrix, integrins and their associated signaling pathways have been shown to be involved in cell proliferation, migration, invasion and survival, processes required in both tumorigenesis and metastasis. beta 1-integrins represent the predominantly expressed integrins in mammary epithelial cells and have been proven crucial for mammary gland development and differentiation. Here we provide an overview of the studies that have used transgenic mouse models of mammary tumorigenesis to establish beta 1-integrin as a critical mediator of breast cancer progression and thereby as a potential therapeutic target for the development of new anticancer strategies.
ISSN:1465-5411
1465-542X
DOI:10.1186/bcr2905