Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs

• Published in: Immunogenetics (New York) 2013-02, Vol.65 (2), p.125-132
• Main Authors: Yang, X., Murani, E., Ponsuksili, S., Wimmers, K.
• Format: Article
• Language: English
• Subjects: Adaptive immunity; Alleles; Allergology; Animal husbandry; Animals; Bacteria; Biology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cytokines; Cytokines - genetics; Cytokines - metabolism; Disease; Disease resistance; Gene Frequency; Gene Function; Genotype; Haplotypes; Hogs; Human Genetics; Immunology; Inflammatory bowel disease; Original Paper; Pneumonia; Polymorphism, Single Nucleotide; RNA, Messenger - genetics; RNA, Messenger - metabolism; Swine; Toll-Like Receptor 5 - genetics; Toll-Like Receptor 5 - metabolism; Transcription, Genetic; Tumor necrosis factor-TNF
• ISSN: 0093-7711; 1432-1211
• DOI: 10.1007/s00251-012-0662-9

The Toll-like receptor 5 (TLR5) plays a crucial role in host defense against flagellated bacteria by recognizing flagellin. Accumulating evidence suggests that single nucleotide polymorphisms (SNPs) in TLR5 have an effect on flagellin recognition and are associated with susceptibility/resistance to disease. In this study, we analyzed association of SNPs, including c.834T>G, c.1065T>C, c.1205C>T, c.1246A>T, c.1269G>A, and c.1398C>T, as well as mRNA level of TLR5 with the abundance of transcripts of cytokines in pigs. SNPs c.1246A>T and c.1269G>A were significantly associated with the transcript abundance of interleukin (IL)-2, and SNPs c.834T>G and c.1398C>T with IL-10 ( P