Disturbed vestibular-neck interaction in cerebellar disease

Cerebellar dysfunction results in ataxia including postural deficits. Evidence from animal experiments suggests convergence of vestibular and neck-position related inputs in cerebellar midline structures. We investigated 20 ambulatory patients with cerebellar disease for disturbed postural control u...

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Bibliographic Details
Published in:Journal of neurology 2013-03, Vol.260 (3), p.794-804
Main Authors: Kammermeier, S., Kleine, J. F., Eggert, T., Krafczyk, S., Büttner, U.
Format: Article
Language:English
Subjects:
Adult
Aged
Ataxia
Cerebellar Diseases - diagnosis
Cerebellar Diseases - physiopathology
Coordinate transformations
Female
Gait Disorders, Neurologic - diagnosis
Gait Disorders, Neurologic - physiopathology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neck - physiology
Neurology
Neuroradiology
Neurosciences
Original Communication
Postural Balance - physiology
Posture
Vestibule, Labyrinth - physiology
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Summary:Cerebellar dysfunction results in ataxia including postural deficits. Evidence from animal experiments suggests convergence of vestibular and neck-position related inputs in cerebellar midline structures. We investigated 20 ambulatory patients with cerebellar disease for disturbed postural control using posturography during static lateral head turns. Binaural bipolar sine-wave galvanic vestibular stimulation (GVS) was used to evoke specific body movements. The Klockgether clinical score was used to assess the severity of cerebellar dysfunction (4–17 of maximal 35 points). In 12 healthy controls and seven lightly affected patients (score
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-012-6707-z