Efficient quenching of electrochemiluminescence from K-doped graphene-CdS:Eu NCs by G-quadruplex-hemin and target recycling-assisted amplification for ultrasensitive DNA biosensing

Based on the K-doped graphene-CdS:Eu NC composites and the nicking endonuclease (NEase) assisted strand-scission cycle, we have developed an ultrasensitive and selective electrochemiluminescence (ECL) DNA biosensor using the G-quadruplex-hemin-based DNAzyme which acts as an electrocatalyst for the r...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-03, Vol.49 (22), p.2246-2248
Main Authors: Zhou, Hong, Zhang, Yan-Yan, Liu, Jing, Xu, Jing-Juan, Chen, Hong-Yuan
Format: Article
Language:English
Subjects:
Biocatalysis
Biosensing Techniques
Biosensors
Cadmium Compounds - chemistry
DNA - analysis
DNA, Catalytic - chemistry
DNA, Catalytic - metabolism
Electrochemical Techniques
Endonucleases - chemistry
Endonucleases - metabolism
Europium - chemistry
G-Quadruplexes
Graphite - chemistry
Hemin - chemistry
Hydrogen Peroxide - chemistry
Hydrogen Peroxide - metabolism
Luminescence
Luminescent Measurements
Nanostructures - chemistry
Oxidation-Reduction
Particle Size
Semiconductors
Sulfides - chemistry
Surface Properties
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Summary:Based on the K-doped graphene-CdS:Eu NC composites and the nicking endonuclease (NEase) assisted strand-scission cycle, we have developed an ultrasensitive and selective electrochemiluminescence (ECL) DNA biosensor using the G-quadruplex-hemin-based DNAzyme which acts as an electrocatalyst for the reduction of H(2)O(2), the coreactant of CdS:Eu NCs ECL.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38990a