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Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients
Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene ( LEP ), which encodes for leptin, have been described. However, its association with obesity is still c...
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| Published in: | Cell biochemistry and biophysics 2013-03, Vol.65 (2), p.243-247 |
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| container_title | Cell biochemistry and biophysics |
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| creator | Sahin, Deniz Say Tumer, Cemil Demir, Cemil Celik, M. Murat Celik, Mustafa Ucar, Edip Gunesacar, Ramazan |
| description | Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (
LEP
), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether
LEP
c.-2548 G>A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction.
LEP
c.-2548 G>A polymorphism were detected using polymerase chain reaction–restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G>A polymorphism in the
LEP
were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %;
p
= 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (
p
|
| doi_str_mv | 10.1007/s12013-012-9427-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1323805536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1323805536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-17005ac8b25b54a64c567c339e5fb40e1605b744c8d0749933af45e9337954a3</originalsourceid><addsrcrecordid>eNqFkd9r1EAQxxdRbHv2D_BFFnzxoamzv5LdF-Fa6lm40kLvPWySOS812Zw7iXr_vXtcKyIUn2ZgPvOdXT6MvRVwLgCKjyQkCJWBkJnTssjEC3YsjHEZSKteph6syZxw5oidED0ASAlav2ZHUoHRTsAx282Jhrr1YzsE_rMdN3yJ27ENfIEBeX2eSaMtX3ya87uh2_VD3G5a6s_4Pcapf2KX-AM7OuM-NPxiaHb8xhPx69DgL57Gqyl-a2nDbysk5HfpFoaR3rBXa98Rnj7WGVt9vlpdfsmWt4vry_kyqzWYMRMFgPG1raSpjPa5rk1e1Eo5NOtKA4ocTFVoXdsGCu2cUn6tDaZauMSrGftwiN3G4fuENJZ9SzV2nQ84TFQKJZUFY1T-f1Rap61SQiX0_T_owzDFkP6xp2wujJM6UeJA1XEgirgut7HtfdyVAsq9wfJgsEwGy73B9JoZe_eYPFU9Nn82npQlQB4ASqPwFeNfp59N_Q2wE6Ij</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1288615924</pqid></control><display><type>article</type><title>Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients</title><source>Springer Nature</source><creator>Sahin, Deniz Say ; Tumer, Cemil ; Demir, Cemil ; Celik, M. Murat ; Celik, Mustafa ; Ucar, Edip ; Gunesacar, Ramazan</creator><creatorcontrib>Sahin, Deniz Say ; Tumer, Cemil ; Demir, Cemil ; Celik, M. Murat ; Celik, Mustafa ; Ucar, Edip ; Gunesacar, Ramazan</creatorcontrib><description>Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (
LEP
), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether
LEP
c.-2548 G>A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction.
LEP
c.-2548 G>A polymorphism were detected using polymerase chain reaction–restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G>A polymorphism in the
LEP
were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %;
p
= 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (
p
< 0.001) and body mass index (
p
< 0.0001). All these consequences showed that
LEP
-2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-012-9427-1</identifier><identifier>PMID: 23054910</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Alleles ; Biochemistry ; Biological and Medical Physics ; Biomarkers - blood ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Body Mass Index ; Cell Biology ; Cholesterol - blood ; Colorimetry ; Energy expenditure ; Enzyme-Linked Immunosorbent Assay ; Food intake ; Gene Frequency ; Gene polymorphism ; Genotype ; Genotypes ; Hormones ; Humans ; Leptin ; Leptin - blood ; Leptin - genetics ; Life Sciences ; Lipids ; Lipoproteins, LDL - blood ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - genetics ; Original Paper ; Pharmacology/Toxicology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Triglycerides - blood ; Turkey</subject><ispartof>Cell biochemistry and biophysics, 2013-03, Vol.65 (2), p.243-247</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-17005ac8b25b54a64c567c339e5fb40e1605b744c8d0749933af45e9337954a3</citedby><cites>FETCH-LOGICAL-c405t-17005ac8b25b54a64c567c339e5fb40e1605b744c8d0749933af45e9337954a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23054910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Deniz Say</creatorcontrib><creatorcontrib>Tumer, Cemil</creatorcontrib><creatorcontrib>Demir, Cemil</creatorcontrib><creatorcontrib>Celik, M. Murat</creatorcontrib><creatorcontrib>Celik, Mustafa</creatorcontrib><creatorcontrib>Ucar, Edip</creatorcontrib><creatorcontrib>Gunesacar, Ramazan</creatorcontrib><title>Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (
LEP
), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether
LEP
c.-2548 G>A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction.
LEP
c.-2548 G>A polymorphism were detected using polymerase chain reaction–restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G>A polymorphism in the
LEP
were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %;
p
= 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (
p
< 0.001) and body mass index (
p
< 0.0001). All these consequences showed that
LEP
-2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Body Mass Index</subject><subject>Cell Biology</subject><subject>Cholesterol - blood</subject><subject>Colorimetry</subject><subject>Energy expenditure</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Food intake</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hormones</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Leptin - genetics</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Lipoproteins, LDL - blood</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - genetics</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Triglycerides - blood</subject><subject>Turkey</subject><issn>1085-9195</issn><issn>1559-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkd9r1EAQxxdRbHv2D_BFFnzxoamzv5LdF-Fa6lm40kLvPWySOS812Zw7iXr_vXtcKyIUn2ZgPvOdXT6MvRVwLgCKjyQkCJWBkJnTssjEC3YsjHEZSKteph6syZxw5oidED0ASAlav2ZHUoHRTsAx282Jhrr1YzsE_rMdN3yJ27ENfIEBeX2eSaMtX3ya87uh2_VD3G5a6s_4Pcapf2KX-AM7OuM-NPxiaHb8xhPx69DgL57Gqyl-a2nDbysk5HfpFoaR3rBXa98Rnj7WGVt9vlpdfsmWt4vry_kyqzWYMRMFgPG1raSpjPa5rk1e1Eo5NOtKA4ocTFVoXdsGCu2cUn6tDaZauMSrGftwiN3G4fuENJZ9SzV2nQ84TFQKJZUFY1T-f1Rap61SQiX0_T_owzDFkP6xp2wujJM6UeJA1XEgirgut7HtfdyVAsq9wfJgsEwGy73B9JoZe_eYPFU9Nn82npQlQB4ASqPwFeNfp59N_Q2wE6Ij</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Sahin, Deniz Say</creator><creator>Tumer, Cemil</creator><creator>Demir, Cemil</creator><creator>Celik, M. 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Murat ; Celik, Mustafa ; Ucar, Edip ; Gunesacar, Ramazan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-17005ac8b25b54a64c567c339e5fb40e1605b744c8d0749933af45e9337954a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Body Mass Index</topic><topic>Cell Biology</topic><topic>Cholesterol - blood</topic><topic>Colorimetry</topic><topic>Energy expenditure</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Food intake</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hormones</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Leptin - genetics</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Lipoproteins, LDL - blood</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - genetics</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Triglycerides - blood</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Deniz Say</creatorcontrib><creatorcontrib>Tumer, Cemil</creatorcontrib><creatorcontrib>Demir, Cemil</creatorcontrib><creatorcontrib>Celik, M. 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Murat</au><au>Celik, Mustafa</au><au>Ucar, Edip</au><au>Gunesacar, Ramazan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients</atitle><jtitle>Cell biochemistry and biophysics</jtitle><stitle>Cell Biochem Biophys</stitle><addtitle>Cell Biochem Biophys</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>65</volume><issue>2</issue><spage>243</spage><epage>247</epage><pages>243-247</pages><issn>1085-9195</issn><eissn>1559-0283</eissn><abstract>Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (
LEP
), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether
LEP
c.-2548 G>A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction.
LEP
c.-2548 G>A polymorphism were detected using polymerase chain reaction–restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G>A polymorphism in the
LEP
were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %;
p
= 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (
p
< 0.001) and body mass index (
p
< 0.0001). All these consequences showed that
LEP
-2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23054910</pmid><doi>10.1007/s12013-012-9427-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cell biochemistry and biophysics, 2013-03, Vol.65 (2), p.243-247 |
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| source | Springer Nature |
| subjects | Adult Alleles Biochemistry Biological and Medical Physics Biomarkers - blood Biomedical and Life Sciences Biophysics Biotechnology Body Mass Index Cell Biology Cholesterol - blood Colorimetry Energy expenditure Enzyme-Linked Immunosorbent Assay Food intake Gene Frequency Gene polymorphism Genotype Genotypes Hormones Humans Leptin Leptin - blood Leptin - genetics Life Sciences Lipids Lipoproteins, LDL - blood Middle Aged Obesity Obesity - blood Obesity - genetics Original Paper Pharmacology/Toxicology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Triglycerides - blood Turkey |
| title | Association with Leptin Gene c.-2548 G>A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients |
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