Nandrolone Decanoate Induces Genetic Damage in Multiple Organs of Rats

To evaluate the impact potential of nandrolone decanoate on DNA damage in multiple organs of Wistar rats by means of single-cell gel (comet) assay and micronucleus test. A total of 15 animals were distributed into three groups of five animals each as follows: control group = animal not exposed to na...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 2013-04, Vol.64 (3), p.514-518
Main Authors: Pozzi, Renan, Fernandes, Kelly Rosseti, de Moura, Carolina Foot Gomes, Ferrari, Raquel Agnelli Mesquita, Fernandes, Kristianne Porta Santos, Renno, Ana Claudia Muniz, Ribeiro, Daniel Araki
Format: Article
Language:English
Subjects:
Anabolic Agents - toxicity
Anabolic steroids
Animal diseases
Animal, plant and microbial ecology
Animals
Applied ecology
Biological and medical sciences
Chemical contaminants
Chromosome aberrations
Chromosomes
Comet Assay
Data Interpretation, Statistical
Deoxyribonucleic acid
DNA
DNA Damage
DNA repair
Dose-Response Relationship, Drug
Earth and Environmental Science
Ecotoxicology
Ecotoxicology, biological effects of pollution
Environment
Environmental Chemistry
Environmental Health
Environmental monitoring
Erythrocytes - drug effects
Erythrocytes - pathology
Fundamental and applied biological sciences. Psychology
General aspects
Genetics
Heart - drug effects
Kidney - drug effects
Kidney - pathology
Kidneys
Laboratory animals
Liver - drug effects
Liver - pathology
Male
Micronuclei, Chromosome-Defective - chemically induced
Micronucleus Tests
Monitoring/Environmental Analysis
Nandrolone - toxicity
Organ Specificity
Pollutants
Pollution
Rats
Rats, Wistar
Rodents
Soil Science & Conservation
Studies
Toxicity
Toxicity Tests
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Summary:To evaluate the impact potential of nandrolone decanoate on DNA damage in multiple organs of Wistar rats by means of single-cell gel (comet) assay and micronucleus test. A total of 15 animals were distributed into three groups of five animals each as follows: control group = animal not exposed to nandrolone decanoate; experimental group = animals exposed to nandrolone decanoate for 24 h at 5 mg/kg subcutaneously; and experimental group = animals exposed to nandrolone decanoate for 24 h at 15 mg/kg subcutaneously. Significant statistical differences ( p  
ISSN:0090-4341
1432-0703
DOI:10.1007/s00244-012-9848-2