Direct detection of unamplified genomic DNA based on photo-induced silver ion reduction by DNA molecules

A label-free, colorimetric method has been developed for ultrasensitive detection of nucleic acids that is based on photoinduced silver ion (Ag(+)) reduction around DNA bases. The assay system is capable of directly detecting bacterial genomic DNA without the need for PCR amplification.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (23), p.2350-2352
Main Authors: Jung, Ye Lim, Jung, Cheulhee, Park, Jung Hun, Kim, Moon Il, Park, Hyun Gyu
Format: Article
Language:English
Subjects:
Chemical communication
Colorimetry
DNA - analysis
Genome, Bacterial
Ions - chemistry
Metal Nanoparticles - chemistry
Oxidation-Reduction
Point-of-Care Systems
Salmonella - genetics
Silver - chemistry
Ultraviolet Rays
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Description
Summary:A label-free, colorimetric method has been developed for ultrasensitive detection of nucleic acids that is based on photoinduced silver ion (Ag(+)) reduction around DNA bases. The assay system is capable of directly detecting bacterial genomic DNA without the need for PCR amplification.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc38552c