Coffee Consumption and Prostate Cancer Aggressiveness Among African and Caucasian Americans in a Population-Based Study

This study evaluated the relationship between caffeinated and decaffeinated coffee and prostate cancer (CaP) aggressiveness using data from a population-based incident CaP study within the North Carolina-Louisiana Prostate Cancer Project (PCaP). Classification of CaP aggressiveness at diagnosis was...

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Bibliographic Details
Published in:Nutrition and cancer 2012-07, Vol.64 (5), p.637-642
Main Authors: Arab, Lenore, Su, L. Joseph, Steck, Susan E, Ang, Alfonso, Fontham, Elizabeth T. H, Bensen, Jeannette T, Mohler, James L
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - epidemiology
Adenocarcinoma - ethnology
Adenocarcinoma - pathology
Adult
African Americans
Aged
Aggressiveness
Caffeine - administration & dosage
Caffeine - adverse effects
Caffeine - therapeutic use
Coffee
Coffee - adverse effects
Correlation analysis
Diet - adverse effects
Diet - ethnology
diet history
European Continental Ancestry Group
Humans
Louisiana - epidemiology
Male
Medical Records
Middle Aged
Neoplasm Staging
North Carolina - epidemiology
Prognosis
Prostate cancer
Prostate-Specific Antigen - blood
prostatic neoplasms
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - ethnology
Prostatic Neoplasms - pathology
questionnaires
Risk
Risk assessment
Surveys and Questionnaires
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Summary:This study evaluated the relationship between caffeinated and decaffeinated coffee and prostate cancer (CaP) aggressiveness using data from a population-based incident CaP study within the North Carolina-Louisiana Prostate Cancer Project (PCaP). Classification of CaP aggressiveness at diagnosis was based on clinical criteria for 1,049 African-American (AA) and 1,083 Caucasian-American (CA) research subjects. Coffee consumption was measured using a modified NCI Dietary History Questionnaire. No significant associations were found between CaP aggressiveness and consumption of either caffeinated or decaffeinated coffee. The OR for high aggressive CaP among consumers of more than 4 cups per day was 0.92 (95%CI = 0.61, 1.39), compared to non-coffee-drinkers. Results stratified by race found no significant associations and no noticeable trends in either AAs (P for trend = 0. 62) or CAs (P for trend = 0.42). In contrast to a recent report on a select population that has less complete information on CaP aggressiveness suggesting that coffee prevents aggressive CaP, this rapid case ascertainment population-based study, in a biracial population with differing risks of CaP did not demonstrate a protective relationship between high coffee consumption and risk of high aggressive CaP.
ISSN:1532-7914
0163-5581
1532-7914
DOI:10.1080/01635581.2012.676144