The kinetics of CD4+ and CD8+ T-cell gene expression correlate with protection in Atlantic salmon ( Salmo salar L) vaccinated against infectious pancreatic necrosis

• Published in: Vaccine 2013-04, Vol.31 (15), p.1956-1963
• Main Authors: Munang’andu, Hetron Mweemba, Fredriksen, Børge Nilsen, Mutoloki, Stephen, Dalmo, Roy Ambli, Evensen, Øystein
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Animals; Antibodies, Viral - analysis; antigens; Applied microbiology; Atlantic salmon; Biological and medical sciences; Birnaviridae Infections - genetics; Birnaviridae Infections - immunology; Birnaviridae Infections - prevention & control; Birnaviridae Infections - veterinary; CD4; CD4-Positive T-Lymphocytes - metabolism; CD8; CD8-positive T-lymphocytes; CD8-Positive T-Lymphocytes - metabolism; Correlate; correlation; Disease Progression; Fish; Fish Diseases - genetics; Fish Diseases - immunology; Fish Diseases - mortality; Fish Diseases - prevention & control; Forkhead Transcription Factors - genetics; Fundamental and applied biological sciences. Psychology; GATA3 Transcription Factor - genetics; Gene expression; gene expression regulation; Gene Expression Regulation - immunology; genes; Granzymes - genetics; immune response; Infections; Infectious pancreatic necrosis virus; Infectious pancreatic necrosis virus - immunology; Lymphoid Tissue - immunology; Lymphoid Tissue - metabolism; Microbiology; Miscellaneous; necrosis; neutralizing antibodies; Protection; Salmo salar; Salmo salar - genetics; Salmo salar - immunology; Salmo salar - virology; Salmon; Spleen; Survival Analysis; Vaccination; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); vertebrates; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; Virology; virulence; viruses
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.02.008

Highlights ► Increase in antibody levels corresponded with reduction of post challenge mortality. ► Increase in antibody levels inversely correlate with increase in viral copy numbers. ► GATA-3 expression positively correlated with increase in antibody levels. ► T-bet and FoxP3 expression positively correlate with increase in viral copy numbers. ► Eomes, CD8α and granzyme A inversely correlated with increase in antibody levels.