Emerging therapies for multidrug resistant Acinetobacter baumannii

The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen. For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary....

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2013-03, Vol.21 (3), p.157-163
Main Authors: García-Quintanilla, Meritxell, Pulido, Marina R, López-Rojas, Rafael, Pachón, Jerónimo, McConnell, Michael J
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter Infections - microbiology
Acinetobacter Infections - prevention & control
Acinetobacter Infections - therapy
antibacterial properties
antibiotic resistance
antibiotics
antimicrobial peptides
Biological Therapy - methods
chelation
Drug Resistance, Multiple, Bacterial
Humans
Internal Medicine
iron chelation therapy
mechanism of action
multiple drug resistance
nitric oxide
pathogens
phage therapy
vaccination
vaccine
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Summary:The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen. For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary. Several studies have begun to characterize nonantibiotic approaches that utilize novel mechanisms of action to achieve antibacterial activity. Recent advances in phage therapy, iron chelation therapy, antimicrobial peptides, prophylactic vaccination, photodynamic therapy, and nitric oxide (NO)-based therapies have all been shown to have activity against A. baumannii. However, before these approaches can be used clinically there are still limitations and remaining questions that must be addressed.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2012.12.002